SENSORY INPUTS FROM THE ORAL-REGION TO THE CEREBRAL-CORTEX IN BEHAVING RATS - AN ANALYSIS OF UNIT RESPONSES IN CORTICAL SOMATOSENSORY AND TASTE AREAS DURING INGESTIVE BEHAVIOR
SENSORY INPUTS FROM THE ORAL-REGION TO THE CEREBRAL-CORTEX IN BEHAVING RATS - AN ANALYSIS OF UNIT RESPONSES IN CORTICAL SOMATOSENSORY AND TASTE AREAS DURING INGESTIVE BEHAVIOR
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DOI：
10.1152/jn.1988.60.4.1303
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发表时间：
1988-10-01
影响因子：
2.5
通讯作者：
KITAMURA, R
中科院分区：
文献类型：
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作者：
YAMAMOTO, T;MATSUO, R;KITAMURA, R
1.在自由活动的Wistar大鼠上，用慢性植入的细导线记录了90个躯体感觉区和味觉区皮层神经元的反应。主要在动物自由舔溶液和进食干颗粒时分析反应。皮质神经元根据其反应特性分为几组。2.“机械敏感”神经元（n=20）表现出有节奏的阶段性活动在舔周期的不同阶段，这取决于他们的感受野在周边orofacial区域的位置。3.“运动相关”神经元（n=27）在舔、咀嚼或梳理行为过程中紧张性地改变其活动。反应是兴奋性或抑制性的。无法识别感受野和适当的刺激。这些神经元可能从口内或口周区域的宽或深的区域接收躯体感觉（除了光触觉）输入，或者可能与口面主动运动有关。4.“味觉”神经元（n=35）增加或减少其放电率舔特定的味道解决方案。一些味觉神经元接受来自躯体感觉输入的会聚。5.“温度”神经元（n=2）只对低于或高于室温的水作出反应。冷刺激和热刺激的反应方向相反。6.“预期”神经元（n=4）增加了他们的冲动放电开始前舔的情况下，动物预期获得饮水管。7.“注意”神经元（n=2）对唤醒刺激（如声音、闪光和身体接触）作出反应。这些神经元在摄食行为期间仅表现出轻微增加的反应。8. 90个单位中有56个单位的位置经组织学鉴定。机械敏感神经元位于颗粒皮质的初级躯体感觉区内的躯体位置模式的适当部分。味觉神经元均匀分布于颗粒异常皮质和无颗粒岛叶皮质。其他类型的神经元主要分布在颗粒皮质和无颗粒胰岛素皮质之间的异常颗粒皮质中，在无颗粒岛叶皮质中有些与味觉神经元混杂。9.本研究表明，口舌体觉区和味觉区的皮层神经元对摄食行为的各个方面具有不同的反应特征。这表明，这些具有不同功能的神经元在皮质内组织良好的解剖结构，这可能有助于背景皮质神经机制，包括整合口舌感觉输入，味觉感知和控制摄食行为。
1. The responses of 90 cortical neurons in the somatosensory and gustatory areas were recorded with chronically implanted fine wires in freely moving Wistar rats. The responses were analyzed mainly while the animals were freely licking solutions and eating dry pellets. Cortical neurons were classified into several groups according to their response properties. 2. "Mechanosensitive" neurons (n=20) showed rhythmic phasic activity in different phases of the licking cycle, depending on the location of their receptive field in the peripheral orofacial region. 3. "Movement-related" neurons (n=27) changed their activities tonically during licking, chewing, or grooming behavior. The responses were either excitatory or inhibitory. Receptive fields and adequate stimuli could not be identified. These neurons might receive somatosensory (except light tactile) inputs from wide or deep areas of intra- or perioral regions, or might be related to orofacial active movement. 4. "Taste" neurons (n=35) increased or decreased their discharge rates during licking of particular taste solutions. Some taste neurons received convergence from somatosensory inputs. 5. "Temperature" neurons (n=2) responded exclusively to water of temperatures lower or higher than room temperature. The responses were opposite in direction between cold and warm stimuli. 6. "Anticipation" neurons (n=4) increased their impulse discharges before the start of licking in the situation in which the animal expected access to the drinking tube. 7. "Attention" neurons (n=2) responded to arousal stimulation such as sound, a flash of light, and body touch. These neurons showed only a slightly increasing response during ingestive behavior. 8. The locations of 56 of 90 units were histologically identified. Mechanosensitive neurons were located in the appropriate parts of the somatotopic pattern within the primary somatic sensory area in the granular cortex. Taste neurons were found evenly in the dysgranular cortex and the agranular insular cortex. Other types of neurons were located mainly in the dysgranular cortex between the granular cortex and agranular insulin cortex, and some were intermingled with taste neurons in the agranular insular cortex. 9. The present study has shown that cortical neurons in the orolingual somatosensory and taste areas have differnet response characteristics related to each aspect of ingestive behavior. It is suggested that these neurons with different functions are well organized anatomically within the cortex, which may subserve the background cortical neural mechanisms involving integration of orolingual sensory inputs, perception of taste, and control of ingestive behavior.