Gender-related differences in IBS symptoms
Gender-related differences in IBS symptoms
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DOI：
10.1111/j.1572-0241.2001.03961.x
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发表时间：
2001-07
影响因子：
9.8
通讯作者：
O. Lee;E. Mayer;M. Schmulson;Lin Chang;B. Naliboff
中科院分区：
文献类型：
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作者：
O. Lee;E. Mayer;M. Schmulson;Lin Chang;B. Naliboff
目的：女性比男性更容易报告肠易激综合征(IBS)症状以及慢性内脏和肌肉骨骼疼痛。这项研究检验了一般假设，即女性IBS患者在内脏和肌肉骨骼系统相关的症状方面与男性患者不同，这些差异与月经周期有关。方法：对714名罗马阳性IBS患者进行了胃肠道和结肠外症状、心理症状(SCL-90R)和生活质量(SF-36)的评估。此外，54名绝经后女性、61名绝经前女性和54名年龄匹配的男性都患有IBS。结果：男性和女性受试者的症状严重程度和心理问题的GI水平相似。与腹胀相关的腹胀和便秘症状在女性患者中更常见。女性患者更常报告恶心、味觉和气味改变、舌头不适、早上肌肉僵硬、对食物更敏感以及药物的副作用。40%的女性患者报告了与月经周期相关的症状恶化，但绝经前和绝经后的女性之间几乎没有发现症状差异，这使得观察到的大多数性别差异不太可能直接与月经周期有关。结论：尽管IBS的严重程度、腹痛、心理症状和疾病影响程度相似，但女性患者报告的各种肠道和非肠道感觉症状水平更高。对非疼痛的内脏感觉、药物和食物的敏感度的明显差异可能代表感觉过程、自主神经反应和/或认知高度警觉的改变。
OBJECTIVE:Women are more likely than men to report irritable bowel syndrome (IBS) symptoms as well as chronic visceral and musculoskeletal pain. The study tests the general hypothesis that female IBS patients differ from their male counterparts in symptoms related to the viscera and musculoskeletal system, and that these differences are related to the menstrual cycle.METHODS:Seven hundred fourteen Rome positive IBS patients were evaluated for GI and extracolonic symptoms, psychological symptoms (SCL-90R), and quality of life (QOL) (SF-36). In addition, 54 postmenopausal women were compared with 61 premenopausal women and 54 age-matched males, all with IBS.RESULTS:Male and female subjects reported similar GI levels of symptom severity and psychological problems. Abdominal distension associated with a sensation of bloating was more commonly reported by female patients, as were symptoms of constipation. Female patients more often reported nausea, alterations of taste and smell, and unpleasant sensations on the tongue, muscle stiffness in the morning, greater food sensitivity, and side effects from medications. Forty percent of female patients reported menstrual cycle–related worsening of symptoms, but few symptom differences were found between pre- and postmenopausal women, making it unlikely that most of the gender differences observed are directly tied to the menstrual cycle.CONCLUSIONS:Female patients report higher levels of a variety of intestinal and nonintestinal sensory symptoms despite similar levels of IBS severity, abdominal pain, psychological symptoms, and illness impact. The apparent differences in sensitivity to nonpainful visceral sensations, medications, and food may represent altered sensory processes, autonomic responses, and/or cognitive hypervigilance.