Influence of Metoprolol Treatment on Sympatho-Adrenal Activation of Fibrinolysis
Influence of Metoprolol Treatment on Sympatho-Adrenal Activation of Fibrinolysis
复制标题
美托洛尔治疗对交感肾上腺纤溶激活的影响
DOI：
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发表时间：
1990
影响因子：
6.7
通讯作者：
Paul Hjemdahl
中科院分区：
文献类型：
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作者：
P. Larsson;Björn Wiman;G. Olsson;Bo Angelin;Paul Hjemdahl
在18名健康男性志愿者中研究了精神应激（色词冲突测试，CWT）和肾上腺素输注（0.1和0.4 nmol kg−1 min−1）对t-PA活性、t-PA抗原、派-1活性和派-1抗原的影响。此外，研究了美托洛尔（200 mg/天，持续1周）或安慰剂（双盲交叉研究）对交感-肾上腺激活的纤溶反应的影响，以及纤溶与血脂之间的关系。低剂量和高剂量肾上腺素输注产生的血浆肾上腺素水平分别为0.9 ± 0.1和3.4 ± 0.4 nmol/l，剂量依赖性地增加t-PA水平，同时降低派-1水平。在CWT期间，当血浆肾上腺素水平仅中度升高（至0.4 ± 0.1 nmol/l）时，似乎发生了类似但较弱的纤溶反应。美托洛尔治疗不影响研究的纤溶变量的静息水平，但倾向于增强t-PA对CWT的反应，并在肾上腺素输注期间进一步降低派-1。美托洛尔治疗不伴随派-1水平的任何升高，尽管药物诱导的甘油三酯水平升高。因此，本研究表明交感-肾上腺激活增加体内纤溶活性，美托洛尔治疗可能对该活性产生有利影响。
Summary The effects of mental stress (a colour word conflict test, CWT) and adrenaline infusions (0.1 and 0.4 nmol kg−1 min−1) on t-PA activity, t-PA antigen, PAI-1 activity and PAI-1 antigen were studied in 18 healthy male volunteers. Furthermore, the effects of metoprolol (200 mg/day during 1 week) or placebo (double-blind cross-over study) on fibrinolytic responses to sympatho-adrenal activation, and relationships between fibrinolysis and blood lipids were investigated. Low and high dose adrenaline infusions yielding plasma adrenaline levels of 0.9 ± 0.1 and 3.4 ± 0.4 nmol/1, respectively, dose-dependently increased t-PA levels with a concomitant decrease in PAI-1 levels. A similar, but weaker, fibrinolytic response seemed to occur during CWT when plasma adrenaline levels were only moderately increased (to 0.4 ± 0.1 nmol/1). Metoprolol treatment did not influence the resting levels of the fibrinolytic variables studied, but tended to enhance the t-PA response to CWT and further reduce PAI-1 during adrenaline infusion. Metoprolol treatment was not accompanied by any rise in PAI-1 levels despite drug induced elevations of triglyceride levels. Thus, the present study shows that sympatho-adrenal activation increases fibrinolytic activity in vivo and that meto prolol treatment may have a favourable influence on this activity.