SOX7: from a developmental regulator to an emerging tumor suppressor.
SOX7: from a developmental regulator to an emerging tumor suppressor.
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DOI：
10.14670/hh-29.10.439
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发表时间：
2014-04
影响因子：
2
通讯作者：
Sui G
中科院分区：
文献类型：
--
作者：
Stovall DB;Cao P;Sui G
SOX7属于转录因子SOX(SRY-Related HMG-box)家族，已被证明在胚胎发育过程中调节多种生物学过程，如造血、血管生成和心脏生成。最近的研究表明，几个SOX家族成员在肿瘤的发生中起着重要的作用。本文介绍了SOX7的基因和蛋白质结构，并讨论了其在肿瘤发生发展中的表达和功能。SOX7在许多人类癌症中经常表达下调，其表达降低与几种癌症的不良预后相关。功能研究揭示了SOX7在前列腺癌、结肠癌、肺癌和乳腺癌中的许多肿瘤抑制特性。到目前为止，虽然SOX7的一些靶基因已经被鉴定出来，但SOX7介导的基因表达还没有在癌症相关的背景下被研究过。我们最近的研究不仅首次证明了SOX7在异种移植小鼠模型中的肿瘤抑制作用，而且揭示了SOX7影响许多调控细胞死亡、生长和凋亡的基因，有力地支持了SOX7在肿瘤发生中的关键作用。因此，目前可用的数据清楚地表明SOX7具有肿瘤抑制作用，但其基因表达和肿瘤抑制活性的机制仍不确定。SOX7在癌症中的研究仍然是一个有待探索的肥沃领域。
SOX7 belongs to the SOX (SRY-related HMG-box) family of transcription factors that have been shown to regulate multiple biological processes, such as hematopoiesis, vasculogenesis and cardiogenesis during embryonic development. Recent studies indicate that several SOX family members play important roles in tumorigenesis. In this review, we introduce SOX7 gene and protein structures, and discuss its expression and functional role in cancer development and progression. SOX7 is frequently downregulated in many human cancers and its reduced expression correlates with poor prognoses of several cancers. Functional studies reveal many tumor suppressive properties of SOX7 in prostate, colon, lung, and breast cancers. To date, although a few target genes of SOX7 have been identified, SOX7-mediated gene expression has not been investigated in a cancer-relevant context. Our recent studies not only for the first time demonstrate a tumor suppressive role of SOX7 in a xenograft mouse model, but also unravel that many genes regulating cell death, growth and apoptosis are affected by SOX7, strongly supporting a pivotal role of SOX7 in tumorigenesis. Thus, currently available data clearly indicate a tumor suppressive role of SOX7, but the mechanisms underlying its gene expression and tumor suppressive activity remain undetermined. The research of SOX7 in cancers remains a fertile area to be explored.