Neuronal Architecture of a Visual Center that Processes Optic Flow
Neuronal Architecture of a Visual Center that Processes Optic Flow
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DOI：
10.1016/j.neuron.2019.04.018
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发表时间：
2019-07-03
期刊：
影响因子：
16.2
通讯作者：
Kubo, Fumi
中科院分区：
文献类型：
--
作者：
Kramer, Anna;Wu, Yunmin;Kubo, Fumi
动物利用全局图像运动线索，通过补偿性运动来主动稳定自己的位置。斑马鱼前盖中的神经元区分不同的光流模式，例如旋转和平移，以驱动适当的行为。结合单细胞的功能成像和形态重建，我们揭示了这种感觉运动转化的关键神经解剖学特征。方向选择性视网膜神经节细胞（DS-RGCs）的末端位于前视网膜树突区5 （AF5）内，在那里它们与前视网膜神经元的树突相遇，可以简单地调节单眼光流。翻译选择性神经元与这些简单细胞混在一起，但不接受DS-RGCs的输入，它们对双眼同一方向的光流有选择性地做出反应。相互排斥的前额叶投射神经元群支配网状结构或小脑，从而控制运动反应。我们假设在定义的保护电路中的局部计算将光流信号转换为驱动光运动行为的神经命令。
Animals use global image motion cues to actively stabilize their position by compensatory movements. Neurons in the zebrafish pretectum distinguish different optic flow patterns, e.g., rotation and translation, to drive appropriate behaviors. Combining functional imaging and morphological reconstruction of single cells, we revealed critical neuroanatomical features of this sensorimotor transformation. Terminals of direction-selective retinal ganglion cells (DS-RGCs) are located within the pretectal retinal arborization field 5 (AF5), where they meet dendrites of pretectal neurons with simple tuning to monocular optic flow. Translation-selective neurons, which respond selectively to optic flow in the same direction for both eyes, are intermingled with these simple cells but do not receive inputs from DS-RGCs. Mutually exclusive populations of pretectal projection neurons innervate either the reticular formation or the cerebellum, which in turn control motor responses. We posit that local computations in a defined pretectal circuit transform optic flow signals into neural commands driving optomotor behavior.