The effects of vitamin A, beta-carotene and canthaxanthin on vitamin A metabolism and immune responses in the chick.
The effects of vitamin A, beta-carotene and canthaxanthin on vitamin A metabolism and immune responses in the chick.
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维生素 A、β-胡萝卜素和角黄素对小鸡维生素 A 代谢和免疫反应的影响。
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
A. Friedman
中科院分区：
文献类型：
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作者：
D. Sklan;T. Yosefov;A. Friedman
雏鸡从孵化时开始饲喂含有0、0.85和350 mg/kg维生素A和1 g/kg β-胡萝卜素或黄原胶的日粮。胡萝卜素增加，黄质降低血浆和肝脏维生素A浓度。高维生素A水平降低了两种类胡萝卜素的浓度。胡萝卜素和黄质均不影响肠内胡萝卜素的体外裂解。T淋巴细胞增殖反应在低维生素A摄入量时降低，在高维生素A摄入量时增强。胡萝卜素和黄质与0.85 mg/kg维生素A喂养对免疫应答没有影响，与350 mg/kg维生素A防止增殖反应的增强。由此可见，维生素A对雏鸡的免疫应答有调节作用，胡萝卜素和黄色素的作用可能是通过影响维生素A的代谢而实现的。
Chicks were fed diets containing, 0, 0.85 and 350 mg/kg vitamin A and 1 g/kg beta-carotene or canthaxanthin from hatching. Carotene increased and canthaxanthin depressed plasma and hepatic vitamin A concentrations. High vitamin A levels decreased the concentration of both carotenoids. Neither carotene nor canthaxanthin affected intestinal carotene cleavage in vitro. T-lymphocyte proliferative responses were decreased at low vitamin A intakes and enhanced at the high vitamin A intake. Carotene and canthaxanthin fed with 0.85 mg/kg vitamin A had no effect on immune response and with 350 mg/kg vitamin A prevented the enhancement of the proliferative response. It is concluded that immune response in the chick is modulated by vitamin A; carotene and canthaxanthin effects are probably due to influences on vitamin A metabolism.