The preterm prediction study: Risk factors for indicated preterm births
The preterm prediction study: Risk factors for indicated preterm births
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DOI：
10.1016/s0002-9378(98)70439-9
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发表时间：
1998-03-01
影响因子：
9.8
通讯作者：
McNellis, D
中科院分区：
文献类型：
--
作者：
Meis, PJ;Goldenberg, RL;McNellis, D
目的：早产的发生有多种原因。R/在查明早产风险因素方面的努力失败，要么忽略原因并将早产视为一个单一实体，要么审查自发早产的风险因素。我们进行了这项研究，以检查指示的早产的危险因素，这占所有早产的四分之一以上。研究设计：这项研究包括10个中心的2929名怀孕24周的妇女。收集了有关人口统计因素、社会经济状况、家庭和工作环境、药物和酒精使用情况以及病史的信息，此外还评估了阴道样本中胎儿纤维连接蛋白和细菌性阴道病的情况，并通过经阴道超声测量了宫颈长度。结果：在怀孕24周的受试者中，15.3%的婴儿出生在30岁(优势比2.42)、黑人(优势比1.56)和孕期工作(优势比1.49)。怀孕期间饮酒实际上与指示早产的风险较低(优势比0.35)有关。结论：本分析中发现的危险因素与自然早产有关。
OBJECTIVE: Preterm births occur for many different reasons. R/lost efforts to identify risk factors for preterm births either ignore cause and consider preterm births as a single entity or examine risk factors for spontaneous preterm births. We performed this study to examine risk factors for indicated preterm births, which constitute more than one quarter of all preterm births.STUDY DESIGN: The study included 2929 women evaluated at 24 weeks' gestation at 10 centers. Information was gathered about demographic factors, socioeconomic status, home and work environments, drug and alcohol use, and medical history In addition vaginal samples were evaluated for fetal fibronectin and bacterial vaginosis and cervical length was measured by transvaginal ultrasonography. Associations with indicated preterm birth were evaluated by univariate tests and by multivariable analysis with logistic regression.RESULTS: Of the women studied at 24 weeks' gestation 15.3% were delivered of their infants at 30 yeats (odds ratio 2.42), black ethnicity (odds ratio 1.56), and working during pregnancy (odds ratio 1.49). Alcohol use in pregnancy was actually associated with a lower risk of indicated preterm birth (odds ratio 0.35).CONCLUSION: The risk factors found in this analysis tend to be different from those associated with spontaneous preterm birth.