Age-related differences in functional network segregation in the context of sex and reproductive stage.
Age-related differences in functional network segregation in the context of sex and reproductive stage.
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DOI：
10.1002/hbm.26184
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发表时间：
2023-04-01
影响因子：
4.8
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中科院分区：
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年龄伴随着功能性大脑网络组织的差异，这会影响成年人的行为。随着年龄的增长，功能性网络变得越来越少，越来越融合。然而，网络隔离的性别差异随着年龄的增长而下降并没有得到很好的理解。此外，在女性生殖阶段的背景下，网络隔离相对研究不足，尽管揭示这种关系对于阐明导致衰老性别特异性差异的生物学机制将是有益的。在目前的工作中，我们使用了来自剑桥老龄化和神经科学中心（Cam-CAN）存储库的数据，以评估性别和生殖阶段产物的静息状态网络隔离的差异。生殖阶段采用生殖老化阶段研讨会（Stages of Reproductive Aging Workshop，10年）标准进行分类。重复先前的工作，我们研究了以下功能网络：听觉，小脑基底神经节，扣带-枕骨任务控制，默认模式，背侧注意，额顶叶任务控制，显著性，感觉躯体运动口，感觉躯体运动手，腹侧注意和视觉。首先，我们的研究结果反映了以前的研究结果，表明网络隔离随着年龄的增长而降低。其次，当分析网络隔离和年龄之间的关联在每个性别分别，我们发现女性和男性之间的质的差异。最后，我们报告了生殖阶段对网络隔离的显着影响，尽管这些发现可能是由年龄驱动的。总的来说，我们的研究结果表明，在调查成年期的网络隔离差异时，性别的影响可能是重要的，尽管需要进一步的工作来确定更年期和性激素对老年女性功能性大脑网络组织的独特作用。我们的研究结果反映了以前的研究结果，表明功能网络隔离随着年龄的增长而降低。在分析网络隔离和年龄与生物性别之间的关联时，我们发现女性和男性之间存在质的差异。最后，我们报告了生殖阶段对功能网络隔离的显着影响，尽管这些发现可能是由年龄驱动的。
Age is accompanied by differences in the organization of functional brain networks, which impact behavior in adulthood. Functional networks become less segregated and more integrated with age. However, sex differences in network segregation declines with age are not well‐understood. Further, network segregation in the context of female reproductive stage is relatively understudied, though unmasking such relationships would be informative for elucidating biological mechanisms that contribute to sex‐specific differences in aging. In the current work, we used data from the Cambridge Centre for Ageing and Neuroscience (Cam‐CAN) repository to evaluate differences in resting‐state network segregation as a product of sex and reproductive stage. Reproductive stage was categorized using the Stages of Reproductive Aging Workshop (STRAW+10) criteria. Replicating prior work, we investigated the following functional networks: auditory, cerebellar‐basal ganglia, cingulo‐opercular task control, default mode, dorsal attention, fronto‐parietal task control, salience, sensory somatomotor mouth, sensory somatomotor hand, ventral attention, and visual. First, our results mirror findings from previous work indicating that network segregation is lower with increasing age. Second, when analyzing associations between network segregation and age within each sex separately, we find qualitative differences between females and males. Finally, we report significant effects of reproductive stage on network segregation, though these findings are likely driven by age. Broadly, our results suggest that impacts of sex may be important to evaluate when investigating network segregation differences across adulthood, though further work is needed to determine the unique role of menopause and sex hormones on the organization of functional brain networks within aging females. Our results mirror findings from previous work indicating that functional network segregation is lower with increasing age. When analyzing associations between network segregation and age with respect to biological sex, we find qualitative differences between females and males. Finally, we report significant effects of reproductive stage on functional network segregation, though these findings are likely driven by age.