Association Between Short-term Exposure to Environmental Air Pollution and Psoriasis Flare
Association Between Short-term Exposure to Environmental Air Pollution and Psoriasis Flare
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DOI：
10.1001/jamadermatol.2021.6019
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发表时间：
2022-02-16
期刊：
影响因子：
10.9
通讯作者：
Gisondi, Paolo
中科院分区：
文献类型：
--
作者：
Bellinato, Francesco;Adami, Giovanni;Gisondi, Paolo
银屑病是一种慢性炎症性疾病，具有复发-缓解过程。选定的环境因素，如感染，压力生活事件或药物可能会引发疾病爆发。空气污染是否会引发银屑病发作仍是未知数。目的探讨短期暴露于环境空气污染是否与银屑病发作有关。这项观察性研究既有病例交叉，也有交叉研究。横断面设计回顾性分析了2013年9月至2020年1月连续就诊的慢性斑块状银屑病患者的纵向数据维罗纳大学医院皮肤科医生。对于病例交叉分析，纳入了至少有1次疾病发作的患者，定义为在3至4个月的时间范围内，2次连续评估之间的银屑病面积和严重程度指数（PASI）增加5或以上。对于横断面分析，患者接受任何系统治疗6个月或更长时间，连续PASI评估为2级或更高。（曲线下面积）几种空气污染物的浓度（一氧化碳、二氧化氮、其他氮氧化物、苯、粗颗粒物[PM;直径2.5-10.0 μ m，PM10]）和细颗粒物[
IMPORTANCE Psoriasis is a chronic inflammatory disease with a relapsing-remitting course. Selected environmental factors such as infections, stressful life events, or drugs may trigger disease flares. Whether air pollution could trigger psoriasis flares is still unknown.OBJECTIVE To investigate whether short-term exposure to environmental air pollution is associated with psoriasis flares.DESIGN, SETTING, AND PARTICIPANTS This observational study with both case-crossover and cross-sectional design retrospectively analyzed longitudinal data from September 2013 to January 2020 from patients with chronic plaque psoriasis consecutively attending the outpatient dermatologic dinic of the University Hospital of Verona. For the case-crossover analysis, patients were included who had at least 1 disease flare, defined as Psoriasis Area and Severity Index (PASI) increase of 5 or greater between 2 consecutive assessments in a time frame of 3 to 4 months. For the cross-sectional analysis, patients were included who received any systemic treatment for 6 or more months, with grade 2 or higher consecutive PASI assessment.MAIN OUTCOMES AND MEASURES We compared the mean and cumulative (area under the curve) concentrations of several air pollutants (carbon monoxide, nitrogen dioxide, other nitrogen oxides, benzene, coarse particulate matter [PM; 2.5-10.0 mu m in diameter, PM10) and fine PM [