CONNECTION BETWEEN PRODUCTION OF PROSTAGLANDINS DURING LIVER-REGENERATION AND DNA SYNTHETIC RESPONSE
CONNECTION BETWEEN PRODUCTION OF PROSTAGLANDINS DURING LIVER-REGENERATION AND DNA SYNTHETIC RESPONSE
复制标题
DOI：
10.1016/0090-6980(76)90064-2
复制
发表时间：
1976-01-01
影响因子：
2.9
通讯作者：
BRACELAND, BM
中科院分区：
文献类型：
--
作者：
MACMANUS, JP;BRACELAND, BM
在肝再生过程中，体内大鼠肝脏中PGE[前列腺素E]等价物的浓度增加。在体外，再生肝组织匀浆合成PGE2和PGF2.pha的能力证实了这种增加反映了PG合成的刺激的可能性。来自花生四烯酸。吲哚美辛阻止了这些PG变化和随后DNA合成的增加。给大鼠注射吲哚美辛可引起低血钙症，并阻断甲状旁腺激素的升钙作用。前列腺素对DNA合成的影响可能与C代谢有关。
The concentration of PGE [prostaglandin E] equivalents in rat liver in vivo increased during liver regeneration. The probability that this increase reflected a stimulation of PG synthesis was confirmed in vitro by the ability of homogenates of regenerating liver tissue to synthesize PGE2 and PGF2.alpha. from arachidonate. Indomethacin prevented these PG changes and the subsequent increase in DNA synthesis. The administration of indomethacin to rats induced a hypocalcemia, and blocked the hypercalcemic action of parathyroid hormone. The influence of prostaglandins on DNA synthesis probably involves C metabolism.