Plasmonic-Fluorescent Janus Ag/Ag2S Nanoparticles for in Situ H2O2-Activated NIR-II Fluorescence Imaging
Plasmonic-Fluorescent Janus Ag/Ag2S Nanoparticles for in Situ H2O2-Activated NIR-II Fluorescence Imaging
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用于原位 H2O2 激活 NIR-II 荧光成像的等离激元荧光 Janus Ag/Ag2S 纳米颗粒
DOI：
10.1021/acs.nanolett.1c00197
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发表时间：
2021
期刊：
影响因子：
10.8
通讯作者：
Duan Hongwei
中科院分区：
文献类型：
--
作者：
Zhang Xuan;Wang Wenli;Su Lichao;Ge Xiaoguang;Ye Jiamin;Zhao Caiyan;He Yu;Yang Huanghao;Song Jibin;Duan Hongwei
硫化银(Ag2S)以其高的荧光量子产率和低的毒性，在近红外(950-1700 nm，NIR-II)二次窗口成像中得到了广泛的关注。然而，它的“始终在线”荧光显示不适用于靶向分子激活的生物医学应用。在这里，我们首次开发了一种新型的银/硫化银JANUS纳米粒子(Ag/Ag2S JNP)，用于在NIR-II窗口中进行特定的可激活荧光成像。激光照射下，粒子内电子从Ag到Ag2S的补偿使JNPs处于荧光的关闭状态，而过氧化氢对Ag的氧化作用减弱了电子转移效应，照亮了Ag2S部分的NIR-II荧光。相反，Ag/Ag2S JNPs的吸收略有下降，表现为激活的光声成像机制。Ag/Ag2S JNPs用于体内疾病的无创定位和诊断，如肝损伤和癌症，具有很高的灵敏度和准确性。
Silver sulfide (Ag2S) has gained widespread attention in second near-infrared (950–1700 nm, NIR-II) window imaging because of its high fluorescence quantum yield and low toxicity. However, its “always on” fluorescence shows inapplicability for targeted molecule-activated biomedical applications. Herein, we first developed a novel silver/silver sulfide Janus nanoparticle (Ag/Ag2S JNP) for specific activatable fluorescence imaging in the NIR-II window. Inner-particle electron compensation from Ag to Ag2S upon laser irradiation endowed JNPs an “off” state of fluorescence, whereas the oxidization of Ag incubated with H2O2, decreasing the electron-transfer effect and illuminating the NIR-II fluorescence of the Ag2S part. In contrast, the absorption of Ag/Ag2S JNPs slightly decreased in an H2O2-dependent manner, showing an activated photoacoustic imaging mechanism. The Ag/Ag2S JNPs were used for noninvasive location and diagnosis of diseasesin vivo, such as for liver injury and cancer, with high sensitivity and accuracy.