Hypocretin I in the lateral hypothalamus activates key feeding‐regulatory brain sites
Hypocretin I in the lateral hypothalamus activates key feeding‐regulatory brain sites
复制标题
下丘脑外侧的下丘脑分泌素 I 激活关键的进食调节大脑部位
作者：
M. Mullett;C. Billington;A. Levine;C. Kotz
下丘脑外侧区注射下丘脑下丘脑下部的下丘脑下丘脑，可刺激大鼠的摄食。本研究旨在探讨黄体生成素注射于黄体生成素所激活的脑区。在黄体生成素注射黄体生成素后，下丘脑外侧隔区、杏仁中央核、伏隔核壳核、终纹床核、黄体生成素、下丘脑后内侧核、穹隆周围核、弓状核、室旁核和孤束核的CFos免疫反应强度显著升高。这些数据表明，下丘脑、边缘和后脑中的其他关键能量调节部位与黄体生成素下丘脑的下丘脑、边缘区域和后脑中的其他关键能量调节部位有联系，并提示这些区域在下丘脑的摄食刺激作用中起着重要作用。
Hypocretin I (also referred to as orexin A) administered into the lateral hypothalamus (LH) stimulates feeding in rats. We undertook the present study to determine the brain regions activated by LH administration of hypocretin I. Hypocretin I administered into the LH significantly elevated cFos-immunoreactivity in the lateral septal area, the central nucleus of the amygdala, the shell of the nucleus accumbens, the bed nucleus of the stria terminalis, the LH, the posterior and dorsomedial hypothalamus, the perifornical, arcuate and paraventricular nuclei and the nucleus of the solitary tract. These data indicate that LH hypocretin I communicates with other key energy regulatory sites within the hypothalamus, the limbic region and the hindbrain, and suggest that these areas are important in the feeding-stimulatory actions of hypocretin I.