Comparative myocardial extraction of two technetium-labeled BATO derivatives (SQ30217, SQ32014) and thallium.
Comparative myocardial extraction of two technetium-labeled BATO derivatives (SQ30217, SQ32014) and thallium.
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发表时间：
1990
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通讯作者：
J. Leppo;D. J. Meerdink
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作者：
J. Leppo;D. J. Meerdink
本文比较了一类新的~（99）mTc标记化合物（BATO）和~（201）Tl在离体兔心血液灌流中的跨毛细血管交换作用。在可变血流量（0.15-2.44 ml/min/g）期间，采用成对指示剂稀释技术测定峰值和净提取（分别为Emax和Enet）以及毛细血管渗透性-表面积乘积（PScap）。对总共13个心脏连续推注201 Tl、[111 In]白蛋白和[99 mTc]BATO;氯[三（环己二酮二肟）甲基硼酸]Tc（SQ 30217，n = 8）和羟基取代衍生物（SQ 32014，n = 5）。平均值（+/-标准差）SQ 30217 Emax和Enet分别为0.72 +/- 0.09和0.55 +/- 0.18，高于铊值0.57 +/- 0.10和0.46 +/- 0.17（p <0.03）。平均SQ 30217 PScap为1.1 +/- 0.4 ml/min/g，也高于相应的铊测定值（0.7 +/- 0.3; p <0.001）。SQ 32014 Emax、Enet和PScap均显著小于铊值（p <0.001）。Emax和PScap的铊和SQ 30217值与血流量密切相关（r大于或等于0.73），而SQ 32014的相关性较弱（r = 0.09）。进行了一项小型临床初步研究（n = 3），结果显示SQ 32014是一种人体心肌灌注不良剂，总之，SQ 30217的跨毛细血管交换大于铊，而铊的跨毛细血管交换又大于SQ 32014。因此，SQ 30217似乎具有良好的临床潜力，但SQ 32014没有。
The transcapillary exchange of a new class of 99mTc-labeled compounds (BATO) were compared to 201Tl in isolated, blood perfused rabbit hearts. During variable blood flow (0.15-2.44 ml/min/g), peak and net extraction (Emax and Enet, respectively), and capillary permeability-surface area product (PScap) were determined with paired indicator-dilution techniques. Serial bolus injections of 201Tl, [111In]albumin, and [99mTc]BATO; chloro[tris(cyclohexanedionedioxime)methyl boronic acid]Tc (SQ30217, n = 8) and a hydroxy-substituted derivative (SQ32014, n = 5) were given to a total of 13 hearts. Mean (+/- s.d.) SQ30217 Emax and Enet were 0.72 +/- 0.09 and 0.55 +/- 0.18, respectively, which were higher than thallium values of 0.57 +/- 0.10 and 0.46 +/- 0.17 (p less than 0.03). Mean SQ30217 PScap was 1.1 +/- 0.4 ml/min/g and was also higher than corresponding thallium determinations (0.7 +/- 0.3; p less than 0.001). SQ32014 Emax, Enet, and PScap were all significantly less than thallium values (p less than 0.001). Thallium and SQ30217 values for Emax and PScap were closely correlated with blood flow (r greater than or equal to 0.73), whereas those for SQ32014 were weakly correlated (r = 0.09). A small clinical pilot study (n = 3) was performed, which showed that SQ32014 was a poor myocardial perfusion agent in man. In summary, transcapillary exchange of SQ30217 is greater than thallium, which in turn, is greater than SQ32014. Therefore, SQ30217 appears to have good clinical potential, but SQ32014 does not.