High expression of AKR1B10 predicts low risk of early tumor recurrence in patients with hepatitis B virus-related hepatocellular carcinoma.
High expression of AKR1B10 predicts low risk of early tumor recurrence in patients with hepatitis B virus-related hepatocellular carcinoma.
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AKR1B10 的高表达预示乙型肝炎病毒相关肝细胞癌患者早期肿瘤复发的风险较低。
DOI：
10.1038/srep42199
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发表时间：
2017-02-09
影响因子：
4.6
通讯作者：
You XM
中科院分区：
文献类型：
--
作者：
Wang YY;Qi LN;Zhong JH;Qin HG;Ye JZ;Lu SD;Ma L;Xiang BD;Li LQ;You XM
为阐明醛酮还原酶家族1成员B10（AKR 1B 10）表达与早期肝细胞癌（HCC）复发的关系，本研究检测了110例接受肝切除术的B肝炎病毒（HBV）相关HCC患者的肿瘤和邻近非肿瘤组织中AKR 1B 10的表达，并分析其与这些患者的临床病理特征和预后的相关性。定量逆转录聚合酶链反应（RT-PCR）检测结果显示，AKR 1B 10 mRNA在肝癌组织中的表达明显高于癌旁组织，而在正常肝组织中的表达水平较低。免疫组化和Western blotting在蛋白质水平证实了类似的结果。AKR 1B 10高表达与血清甲胎蛋白水平呈负相关，与HBV-DNA水平呈正相关。肝切除术后2年内，AKR 1B 10高表达患者的无病生存率显著高于低表达患者。多变量分析也证实AKR 1B 10高表达是早期HCC复发低风险的预测因子。此外，AKR 1B 10高表达被认为是总生存率的有利因素。这些结果表明，AKR 1B 10参与了HBV相关的肝癌发生，但其高表达可以预测HBV相关的HCC患者肝切除术后早期肿瘤复发的风险较低。
To clarify the relationship between aldo-keto reductase family 1 member B10 (AKR1B10) expression and early hepatocellular carcinoma (HCC) recurrence, this study detected AKR1B10 expression in tumor and adjacent non-tumor tissues from 110 patients with hepatitis B virus (HBV)-related HCC underwent liver resection and analyzed its correlations with clinicopathological characteristics and prognosis of these patients. Detected by quantitative reverse transcription polymerase chain reaction, AKR1B10 mRNA expression showed significantly higher in HCC tissues than in adjacent non-tumor tissues, with a low level in normal liver tissues. Similar results was confirmed at the protein level using immunohistochemistry and Western blotting. High AKR1B10 expression was negatively correlated with serum alpha-fetoprotein level and positively correlated with HBV-DNA level. Patients with high AKR1B10 expression had significantly higher disease-free survival than those with low expression within 2 years after liver resection. Multivariate analysis also confirmed high AKR1B10 expression to be a predictor of low risk of early HCC recurrence. In addition, high AKR1B10 expression was found to be a favorable factor of overall survival. These results suggest that AKR1B10 is involved in HBV-related hepatocarcinogenesis, but its high expression could predict low risk of early tumor recurrence in patients with HBV-related HCC after liver resection.