Effect of isoflurane + N2O inhalation and propofol + fentanyl anesthesia on myocardial function as assessed by cardiac troponin, caspase-3, cyclooxygenase-2 and inducible nitric oxide synthase expression.
Effect of isoflurane + N2O inhalation and propofol + fentanyl anesthesia on myocardial function as assessed by cardiac troponin, caspase-3, cyclooxygenase-2 and inducible nitric oxide synthase expression.
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DOI：
10.3892/etm.2017.5029
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发表时间：
2017-11
影响因子：
2.7
通讯作者：
Zhuanghui Zhu;Shuanglian Yi;Z. Shan;Hongwei Guo;Shaofan Ke
中科院分区：
文献类型：
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作者：
Zhuanghui Zhu;Shuanglian Yi;Z. Shan;Hongwei Guo;Shaofan Ke
本研究的目的是评价异氟醚+N2 O吸入和丙泊酚+芬太尼麻醉对心肌肌钙蛋白T（cTnT）评估的心肌功能的影响。将60例患者随机分为异氟醚+N2 O吸入麻醉组（n=30）和丙泊酚+芬太尼麻醉组（n=30）。结果表明，在cTnT水平、人口统计学特征或血流动力学参数方面，两个实验组之间没有显著差异。在大鼠心肌梗死模型上，分别观察了异氟醚+N_2O吸入和丙泊酚+芬太尼麻醉。心肌细胞损伤、炎症和氧化应激水平、caspase-3/9活性和环氧合酶-2蛋白表达均明显降低，但两组间差异无统计学意义。异氟醚+N2 O吸入组诱导型一氧化氮合酶蛋白表达明显高于丙泊酚+芬太尼组（P<0.01）。总之，异氟烷+N2 O吸入和丙泊酚+芬太尼麻醉与心肌功能风险无关。
The aim of this study was to evaluate the effect of isoflurane + N2O inhalation and propofol + fentanyl anesthesia on myocardial function as assessed by cardiac troponin T (cTnT). A total of 60 patients were randomized into two groups: isoflurane + N2O inhalation (n=30) and propofol + fentanyl anesthesia (n=30). The findings demonstrated that there was no significant difference between the two experimental groups in terms of cTnT levels, demographic properties or hemodynamic parameters. Isoflurane + N2O inhalation and propofol + fentanyl anesthesia, respectively, were also investigated in a rat model of myocardial infarction. Myocardial cell damage, inflammation and oxidative stress levels, caspase-3/9 activities and cyclooxygenase-2 protein expression were markedly decreased, although there was no statistical significance difference between the two experimental groups. Notably, inducible nitric oxide synthase protein expression in the isoflurane + N2O inhalation group was significantly higher than that of the propofol + fentanyl anesthesia group (P<0.01). In conclusion, isoflurane + N2O inhalation and propofol + fentanyl anesthesia are not associated with risks for myocardial function.