Pot, atom and step economic (PASE) synthesis of highly functionalized piperidines: a five-component condensation
Pot, atom and step economic (PASE) synthesis of highly functionalized piperidines: a five-component condensation
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DOI：
10.1016/j.tetlet.2007.05.141
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发表时间：
2007-07-23
影响因子：
1.8
通讯作者：
Whtwoo, Adrian C.
中科院分区：
文献类型：
--
作者：
Clarke, Paul A.;Zaytzev, Andrey V.;Whtwoo, Adrian C.
实现了高度功能化的哌啶类化合物的非对映选择性锅、原子和步骤经济(PASE)合成。该过程简单地包括在InCl3存在下将乙酰乙酸甲酯、2当量的醛和2当量的苯胺混合在一起。在大多数情况下，哌啶从溶液中析出。(C)2007爱思唯尔有限公司。保留所有权利。
The diastereoselective pot, atom and step economic (PASE) synthesis of highly functionalized piperidines has been realized. The procedure simply involves mixing methyl acetoacetate, 2 equiv of aldehyde and 2 equiv of aniline together in the presence of InCl3. In most cases the piperidine precipitates out of solution. (c) 2007 Elsevier Ltd. All rights reserved.