A CMOS impedance cytometer for 3D flowing single-cell real-time analysis with ΔΣ error correction
A CMOS impedance cytometer for 3D flowing single-cell real-time analysis with ΔΣ error correction
复制标题
CMOS 阻抗细胞仪，用于 3D 流动单细胞实时分析，具有 ΔΣ 误差校正
DOI：
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
G. Cho
中科院分区：
文献类型：
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作者：
Kang;Jeonghun Nam;Sukhwan Choi;Hyunjung Lim;Sehyun Shin;G. Cho
流式细胞术是临床免疫学和血液学中用于疾病诊断和预后判断的一项重要的细胞分析技术。它涉及细胞的计数、识别和分类[1，2]。传统的体积测量[3]需要大量的血液，当只有很小百分比的细胞含有疾病的证据时，这对于疾病的早期检测是不可取的。在这篇论文中，我们首次提出了一种非侵入性和高通量的单细胞分析方法，该方法使用CMOS集成电路和微流控通道作为完整细胞分选设备的第一个构建块。
Flow cytometry is an essential cell analysis technology in clinical immunology and haematology for the diagnosis and prognosis of disease. It involves the counting, identification and sorting of cells [1,2]. Conventional bulk measurements [3] require a large volume of blood, which is not desirable for the early detection of a disease, when only a very small percentage of cells contain evidence of the disease. In this paper, we propose, for the first time, a non-invasive and high-throughput single-cell analysis method using CMOS-integrated circuits in conjunction with a microfluidic channel as the first building block of a complete cell-sorting device.