Interferon treatment for chronic hepatitis C infection in hemophiliacs--influence of virus load, genotype, and liver pathology on response.
Interferon treatment for chronic hepatitis C infection in hemophiliacs--influence of virus load, genotype, and liver pathology on response.
复制标题
干扰素治疗血友病患者慢性丙型肝炎感染——病毒载量、基因型和肝脏病理学对反应的影响。
DOI：
10.1182/blood.v87.5.1704.bloodjournal8751704
复制
发表时间：
1996
期刊：
影响因子：
20.3
通讯作者：
C. A. Ludlam
中科院分区：
文献类型：
--
作者：
John Hanley;L. Jarvis;J. Andrew;Rosemary Dennis;P. Hayes;J. Piris;R. Lee;P. Simmonds;C. A. Ludlam
In this study, we assessed the effectiveness of interferon treatment in 31 hemophiliacs with chronic hepatitis C virus (HCV) infection. Interferon alfa-2a (3 MU three times weekly) was administered for 6 months. Response was assessed by both serial alanine transaminase (ALT) and HCV RNA levels measured by a sensitive semiquantitative polymerase chain reaction (PCR) method. HCV genotype was determined by restriction fragment length polymorphism (RFLP), and evidence of changing genotypes during interferon therapy was sought. Severity of liver disease was assessed by both noninvasive and invasive methods, including laparoscopic liver inspection and biopsy. Sustained normalization of ALT levels occurred in eight patients (28%), and seven (24%) became nonviremic as assessed by PCR (<80 HCV/mL). Responders universally cleared HCV RNA within 2 months of starting interferon. Genotype 3a was associated with a favorable response to interferon. No evidence was found for a change in circulating genotype in patients who failed to respond to interferon or who relapsed. This study confirms that response rates to interferon are low in hemophiliacs as compared with other groups with chronic HCV infection. We have also demonstrated that virus load measurement over the first 8 to 12 weeks of treatment is an extremely useful method to identify responders at an early stage.
慢性丙型肝炎对干扰素-α的生化和病毒学反应之间的差异。
DOI：
10.1016/0140-6736(93)92187-x
发表时间：
1993
期刊：
Lancet (London, England)
影响因子：
--
作者：
Lau,JY;Mizokami,M;Ohno,T;Diamond,DA;Kniffen,J;Davis,GL
通讯作者：
Davis,GL