Clinical and serological features of mesangial IgA glomerulonephritis.
Clinical and serological features of mesangial IgA glomerulonephritis.
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系膜 IgA 肾小球肾炎的临床和血清学特征。
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
E. Ritz
中科院分区：
文献类型：
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作者：
M. Rambausek;H. Seelig;K. Andrassy;R. Waldherr;V. Lenhard;E. Ritz
IgA-肾小球肾炎（IgA-GN）约占我们单位所有肾小球肾炎的20%。50例IgA-GN患者中有17例发生肾功能衰竭，在平均68个月的随访过程中，11例出现肾功能衰竭。3例患者需要血液透析。50例患者中22例为高血压，5例为恶性高血压。在29%的IgA-GN患者和19%的其他GN患者的皮肤活检中发现了血管周围伊加沉积，但在健康对照组中没有发现。粘液（唾液和鼻腔）分泌型伊加浓度正常。在皮肤和肾小球伊加/IgM沉积物中，使用单克隆抗体证明了IgA 1。未发现HLA-A、B或DR抗原过量，临床病程与HLA-Bw 35无关。
IgA-glomerulonephritis (IgA-GN) accounts for approximately 20 per cent of all glomerulonephritis in our unit. Seventeen out of 50 patients with IgA-GN developed renal failure, which appeared in 11 out of 17 over the course of a mean follow-up of 68 months. Haemodialysis was required in three patients. Twenty-two out of 50 patients had hypertension, five with malignant hypertension. Perivascular IgA deposits were found in skin biopsies of 29 per cent of patients with IgA-GN and also in 19 per cent of patients with other GN, but not in healthy controls. Mucosal (salivary and nasal) secretory IgA concentrations were normal. In cutaneous and glomerular IgA/IgM deposits, IgA1 was demonstrated using monoclonal antibodies. No excess of HLA-A, B or DR antigens and no relation of clinical course and HLA-Bw35 were found.