Effects of old age on vascular complexity and dispersion of the hepatic sinusoidal network.
Effects of old age on vascular complexity and dispersion of the hepatic sinusoidal network.
复制标题
老年对血管复杂性和肝窦网络分散的影响。
DOI：
10.1080/10739680701600856
复制
发表时间：
2008
期刊：
影响因子：
--
通讯作者：
LeCouteur,DavidG
中科院分区：
文献类型：
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作者：
Warren,Alessandra;Chaberek,Slawomir;Ostrowski,Kazimierz;Cogger,VictoriaC;Hilmer,SarahN;McCuskey,RobertS;Fraser,Robin;LeCouteur,DavidG
目的：老年肝窦内皮细胞结构和肝脏血流灌注量均有明显变化。本研究的目的是确定是否也存在可能影响肝功能的肝脏微血管构筑和血管弥散的增龄变化。方法：比较青年(4月龄)和老年(24月龄)大鼠肝脏的血管腐蚀管型和光镜下的变化。使用了分形和傅立叶分析以及微电脑断层扫描。在脉冲响应实验中，根据蔗糖和100 nm微球的分散数来确定血管的弥散度。结果：年龄不影响正弦尺寸、正弦密度或分散数。由分维和各向异性程度决定，肝窦网络的几何形状和复杂性发生了变化。结论：肝窦网络的结构存在微小的、与年龄相关的变化，这些变化可能影响肝功能，并反映更广泛的微循环增龄变化。然而，肝窦大小和肝血管离散度不受年龄的显著影响。
Objectives: In old age, there are marked changes in both the structure of the liver sinusoidal endothelial cell and liver perfusion. The objective of this study was to determine whether there are also aging changes in the microvascular architecture and vascular dispersion of the liver that might influence liver function.Methods: Vascular corrosion casts and light micrographs of young (4 months) and old (24 months) rat livers were compared. Fractal and Fourier analyses and micro-computed tomography were used. Vascular dispersion was determined from the dispersion number for sucrose and 100-nm microspheres in impulse response experiments.Results: Age did not affect sinusoidal dimensions, sinusoidal density, or dispersion number. There were changes in the geometry and complexity of the sinusoidal network as determined by fractal dimension and degree of anisotropy.Conclusions: There are small, age-related changes in the architecture of the liver sinusoidal network, which may influence hepatic function and reflect broader aging changes in the microcirculation. However, sinusoidal dimensions and hepatic vascular dispersion are not markedly influenced by old age.