Primary pulmonary leiomyosarcoma: A population-based study
Primary pulmonary leiomyosarcoma: A population-based study
复制标题
原发性肺平滑肌肉瘤：一项基于人群的研究
DOI：
10.1016/j.lungcan.2017.12.015
复制
发表时间：
2018-02-01
期刊：
影响因子：
5.3
通讯作者：
Zang, Yuan-Sheng
中科院分区：
文献类型：
--
作者：
Qin, Bao-Dong;Jiao, Xiao-Dong;Zang, Yuan-Sheng
目的：原发性肺平滑肌肉瘤是一种罕见的诊断，其临床病理特征和疾病进展知之甚少。我们所知道的是来自有限的病例报告，因此识别与患者生存相关的特征是有必要的。材料和方法：使用前瞻性提取的数据进行人群队列研究，这些数据来自1973年至2013年组织学诊断为PPL的患者的监测、流行病学和最终结果（SEER）数据库，包括人口统计学、治疗和结局数据。共纳入231例PPL患者（平均年龄65.8 ± 14.9岁）。43个被归类为区域阶段，60个被归类为局部阶段，而70个被归类为遥远阶段。大多数（60.4%）患者接受了癌症导向手术，14.1%的患者接受了放射治疗。中位总生存期（OS）为14.0个月，PPL患者的1年、3年和5年OS分别为52.7%、29.0%和22.2%。癌症定向手术使PPL患者的中位OS显着改善了近29.0个月（33.0 vs 4.0个月; p
Objectives: Primary pulmonary leiomyosarcoma (PPL) is a rare diagnosis with poorly understood clinicopathological characteristics and disease progression. What we know is derived from limited case reports, so identification of features associated with patient survival is warranted.Materials and methods: A population cohort study was conducted using prospectively extracted data from the Surveillance, Epidemiology and End Results (SEER) database for patients with histological diagnoses of PPL from 1973 to 2013 including demographic, treatment and outcome data.Results: A total of 231 patients with PPL were included (mean 65.8 +/- 14.9 years-of-age). 43 were categorized with a regional stage, and 60 had localized stage, whereas 70 had distant stage. Most (60.4%) patients received cancer-directed surgery, and radiotherapy was performed for 14.1% of patients. Median overall survival (OS) was 14.0 months, and 1-, 3- and 5-year OS for PPL patients was 52.7%, 29.0% and 22.2%, respectively. Cancer directed surgery significantly improved median OS for patients with PPL by almost 29.0 months (33.0 vs 4.0 months; p