Antiphospholipid antibody positivity and the thrombotic risk in Japanese patients with anti-neutrophil cytoplasmic antibody-associated vasculitis
Antiphospholipid antibody positivity and the thrombotic risk in Japanese patients with anti-neutrophil cytoplasmic antibody-associated vasculitis
复制标题
日本抗中性粒细胞胞浆抗体相关性血管炎患者的抗磷脂抗体阳性和血栓形成风险
DOI：
10.1093/mr/roac031
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发表时间：
2022
影响因子：
2.2
通讯作者：
Nakajima Hiroshi
中科院分区：
文献类型：
--
作者：
Suzuki Junya;Furuta Shunsuke;Sugiyama Takahiro;Iwamoto Taro;Ikeda Kei;Suzuki Kotaro;Nakajima Hiroshi
抗中性粒细胞胞浆抗体相关性血管炎（anti-neutrophil cytoplasmic antibody-associated vasculitis，AAV）患者抗磷脂抗体（antiphospholipid antibody，aPL）阳性率为21.0-51.7%。然而，AAV.MethodsWe回顾性评估2013年至2020年在我院诊断的AAV患者的aPL阳性的临床意义还没有完全理解。aPL阳性定义为随访期间至少一次抗心磷脂抗体、抗心磷脂β2糖蛋白1复合物抗体和/或狼疮抗凝剂阳性。aPL阳性的血栓形成风险进行了检查，多变量分析与考克斯回归model.ResultsA共93例中位年龄为71.9岁的患者被列入研究。中位随访期为35.4个月。aPL阳性31例（33.3%）。17例患者（18.3%）发生了22起血栓形成事件。aPL阳性患者血栓事件发生率高于aPL阴性患者（P= 0.011）。多变量分析与两种不同的模型确定aPL阳性作为血栓形成的危险因素（风险比4.302和5.956，95%置信区间分别为1.546-11.968和1.940-18.281）。
ObjectivesIt has been reported that 21.0–51.7% of anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) patients were antiphospholipid antibody (aPL)-positive. However, the clinical significance of aPL positivity in AAV is not fully understood.MethodsWe retrospectively assessed patients with AAV diagnosed from 2013 to 2020 at our hospital. Positivity of aPL was defined as positivity of anti-cardiolipin antibody, anti-cardiolipin β2 glycoprotein 1 complex antibody, and/or lupus anticoagulant at least one time during the follow-up periods. The thrombotic risk of aPL positivity was examined by multivariate analyses with the Cox regression model.ResultsA total of 93 patients with a median age of 71.9 years were included in the study. The median follow-up period was 35.4 months. Thirty-one patients (33.3%) were aPL-positive. Twenty-two thrombotic events occurred in 17 patients (18.3%). Thrombotic events occurred more frequently in aPL-positive patients than in aPL-negative patients (P= 0.011). Multivariate analyses with two different models identified aPL positivity as a thrombotic risk factor (hazard ratios 4.302 and 5.956, 95% confidence intervals 1.546–11.968 and 1.940–18.281, respectively).ConclusionsThe proportion of aPL-positive patients was 33.3%, and aPL positivity increased the thrombotic risk in Japanese patients with AAV.