Diabetic Rodent Models for Chronic Stroke Studies.
Diabetic Rodent Models for Chronic Stroke Studies.
复制标题
用于慢性中风研究的糖尿病啮齿动物模型。
DOI：
10.1007/978-1-0716-2926-0_30
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Dave,KunjanR
中科院分区：
文献类型：
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作者：
Dalco,LeaJulie;Dave,KunjanR
慢性糖尿病可能会导致中风等继发性并发症，还会增加中风后的脑损伤。在卒中研究中，卒中治疗学术行业圆桌会议(STAIR)确定了增加临床前研究的翻译价值的标准，这突显了使用合并症动物模型的重要性。许多动物模型被用来研究糖尿病患者缺血性脑损伤的加重。在本章中，我们讨论了链脲佐菌素(STZ)诱导的大鼠和小鼠糖尿病模型，并提供了一种有效的方法。我们还提供了自发性糖尿病啮齿动物模型的概述。我们介绍了在每种啮齿动物模型中糖尿病的不同病理生理特征以及每种模型的优缺点。利用这些模型可能有助于新的治疗方法和疗法的进步，以降低糖尿病患者的缺血性脑损伤。
Chronic diabetes may cause secondary complications like stroke and also increase post-stroke brain damage. In stroke research, the Stroke Therapy Academic Industry Roundtable (STAIR) identified criteria to increase translational value of preclinical studies, which highlighted the importance of using animal models of comorbidities. Numerous animal models have been used to study the aggravation of ischemic brain damage in diabetics. In this chapter, we discuss rat and mouse models of streptozotocin (STZ)-induced diabetes, with an efficient method provided. We also provide an overview of spontaneously diabetic rodent models. We present different pathophysiological features of diabetes in each rodent model along with the advantages and disadvantages of each model. Utilizing these models may aid the advancement of novel treatments and therapies to lower ischemic brain damage in patients of diabetes.