TGFB1 and TGFBR1 polymorphic variants in relationship to bladder cancer risk and prognosis.
TGFB1 and TGFBR1 polymorphic variants in relationship to bladder cancer risk and prognosis.
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DOI：
10.1002/ijc.24013
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发表时间：
2009-02-01
影响因子：
6.4
通讯作者：
Real FX
中科院分区：
文献类型：
--
作者：
Castillejo A;Rothman N;Murta-Nascimento C;Malats N;García-Closas M;Gómez-Martínez A;Lloreta J;Tardón A;Serra C;García-Closas R;Chanock S;Silverman DT;Dosemeci M;Kogevinas M;Carrato A;Soto JL;Real FX
TGF-β信号通路在肿瘤的发生和发展中起着重要作用。我们的目的是分析编码TGF-β信号通路的两个关键成员（TGFB 1和TGFBR 1）的基因中的七种不同的常见变体是否与膀胱癌风险以及预后相关。共有1,157例膀胱尿路上皮细胞癌患者和1,157例匹配的对照者进行了TGFB 1中三个SNP（rs 1982073，rs 1800472，rs 1800471）和TGFBR 1中另外三个SNP和一个indel多态性（分别为rs 868，rs 928180，rs334358和rs 11466445）的基因分型。在病例对照研究中，我们使用非条件logistic回归对年龄、性别、研究区域和吸烟状况进行调整，估计每个个体遗传变异的优势比和95%置信区间。采用Kaplan-Meier法和考克斯模型进行生存分析。关注的终点是肿瘤复发、进展和膀胱癌死亡。所有分析的SNPs在病例组和对照组中的分布相似。TGFBR 1 *6A等位基因（rs 11466445）在病例组和对照组中的分布也相似，表明与膀胱癌风险无关。同样，没有一个单倍型与膀胱癌风险显著相关。在肌肉浸润性肿瘤患者中，我们发现TGFBR 1-rs 868与疾病特异性死亡率之间存在显著相关性，且具有等位基因剂量效应（p趋势=0.003）。总之，分析的遗传变异与膀胱癌风险增加无关。TGFBR 1-rs 868与预后的相关性应在独立的患者系列中进行验证。
The TGF-β signalling pathway plays an important role in tumor development and progression. We aimed at analyzing whether seven different common variants in genes coding for two key members of the TGF-β signalling pathway (TGFB1 and TGFBR1) are associated with bladder cancer risk as well as prognosis. A total of 1,157 cases with urothelial cell carcinoma of the bladder and 1,157 matched controls where genotyped for three SNPs in TGFB1 (rs1982073, rs1800472, rs1800471) and an additional three SNPs and one indel polymorphism in TGFBR1 (rs868, rs928180, rs334358, and rs11466445, respectively). In the case-control study, we estimated odds ratios and 95% confidence intervals for each individual genetic variant using unconditional logistic regression adjusting for age, gender, study area and smoking status. Survival analysis was performed using the Kaplan-Meier method and Cox models. The endpoints of interest were tumor relapse, progression, and death from bladder cancer. All the SNPs analyzed showed a similar distribution among cases and controls. The distribution of the TGFBR1*6A allele (rs11466445) was also similar among cases and controls, indicating no association with bladder cancer risk. Similarly, none of the haplotypes was significantly associated with bladder cancer risk. Among patients with muscle-invasive tumors, we found a significant association between TGFBR1-rs868 and disease-specific mortality with an allele dosage effect (p-trend=0.003). In conclusion, the genetic variants analysed were not associated with an increased risk of bladder cancer. The association of TGFBR1-rs868 with outcome should be validated in independent patient series.
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影响因子：
5.8
作者：
Sole, Xavier;Guino, Elisabet;Moreno, Vitor
通讯作者：
Moreno, Vitor
影响因子：
5.8
作者：
Tregouet, D. A.;Garelle, V.
通讯作者：
Garelle, V.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
45.3
作者：
Kaklamani, VG;Hou, NJ;Pasche, B
通讯作者：
Pasche, B
影响因子：
5
作者：
Wei, Ye-Sheng;Zhu, Yin-Hua;Zhang, Lin
通讯作者：
Zhang, Lin