EFFECT OF ASCORBIC-ACID ON URIC-ACID EXCRETION WITH A COMMENTARY ON RENAL HANDLING OF ASCORBIC-ACID
EFFECT OF ASCORBIC-ACID ON URIC-ACID EXCRETION WITH A COMMENTARY ON RENAL HANDLING OF ASCORBIC-ACID
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DOI：
10.1016/0002-9343(77)90351-5
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发表时间：
1977-01-01
影响因子：
5.9
通讯作者：
YU, TF
中科院分区：
文献类型：
--
作者：
BERGER, L;GERSON, CD;YU, TF
在人和狗的自发条件下，尿液中几乎没有抗坏血酸的排泄。当静脉注射增加血浆抗坏血酸时，抗坏血酸清除量(抗坏血酸)迅速增加。注射。当人和狗的血浆抗坏血酸水平升高到12毫克/100毫升和28毫克/100毫升时，无论是人还是狗都没有表现出抗坏血酸的净肾小管分泌。然而，在男性和达尔马提亚犬中，当描述肾小球滤过率(GFR)时，排出的抗坏血酸与滤过量的关系被夸大了，因此抗坏血酸：GFR接近于1。分泌型抗坏血酸在正常情况下可能被掩盖，在低GFR条件下，分泌型抗坏血酸的贡献变得更加明显。在男性中，当血浆抗坏血酸水平提高到6毫克/100ml以上时，肾小球滤过率从对照组的0.081.+-升高。0.020至0.116。+-。0.026。在杂种狗和斑点狗身上，抗坏血酸对尿酸排泄的影响并不是决定性的。人类体内抗坏血酸的尿酸效应可能是由于与尿酸竞争肾小管重吸收转运所致。与人类相比，狗体内抗坏血酸代谢的差异可能有助于解释为什么狗体内抗坏血酸对尿酸排泄的影响不一致。
Under spontaneous conditions in man and dog, very little ascorbic acid is excreted in urine. Ascorbic acid clearance (Cascorbic acid) is promptly augmented when plasma ascorbic acid is increased by i.v. injection. No net tubular secretion of ascorbic acid is demonstrable in either man or dog when plasma ascorbic acid is elevated to levels as high as 12 mg/100 ml in man, and 28 mg/100 ml in the dog. Nevertheless, both in men and the Dalmatian dog, when the glomerular filtration rate (GFR) is described, excreted ascorbic acid in relation to the amount filtered is exaggerated so that Cascorbic acid:GFR approaches unity. Secreted ascorbic acid is possibly masked under ordinary circumstances, with a more significant contribution of secreted ascorbic acid becoming apparent under conditions of low GFR. In man, when the plasma ascorbic acid level is raised to above 6 mg/100 ml, Curate:GFR rises from control value of 0.081 .+-. 0.020, to 0.116 .+-. 0.026. In both mongrel and Dalmatian dogs an effect of ascorbic acid on urate excretion is not conclusively shown. The uricosuric effect of ascorbic acid in man may be due to competition with uric acid for renal tubular reabsorptive transport. The difference in the metabolism of ascorbic acid in the dog as compared to man may help account for the inconsistent effect of ascorbic acid on uric acid excretion in the dog.