New Insights on Lipedema: The Enigmatic Disease of the Peripheral Fat
New Insights on Lipedema: The Enigmatic Disease of the Peripheral Fat
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DOI：
10.1097/prs.0000000000006280
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发表时间：
2019-12-01
影响因子：
3.6
通讯作者：
Machens, Hans-Guenther
中科院分区：
文献类型：
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作者：
Bauer, Anna-Theresa;von Lukowicz, Dominik;Machens, Hans-Guenther
背景：尽管全世界有大量成年女性受到脂肪水肿的影响，但引发这种慢性疾病发病和进展的生理条件仍然是个谜。在本研究中，描述了术后脂肪水肿患者的流行病学情况。方法：作者为德国脂肪水肿患者制作了一份在线调查问卷。该调查针对209名被诊断患有脂肪水肿并接受肿胀吸脂术的女性患者进行。结果：大多数参与者（平均年龄 38.5 岁）在 16 岁时就注意到了该疾病的首次表现。平均需要 15 年才能完成诊断。大多数患者证实，吸脂术可以显着减轻疼痛、肿胀、压痛和容易瘀伤的情况。甲状腺功能减退症 [n = 75 (35.9%) 和抑郁症 [n = 48 (23.0%)] 的发生频率远远超出德国人口的平均患病率。受访者中 1 型糖尿病 [n = 3 (1.4%)] 和 2 型糖尿病 [n = 2 (1%)] 的患病率特别低。 47 名脂肪水肿患者（约占 22.5%）患有偏头痛。 32 名患者 (68.1%) 表示，吸脂术后，偏头痛发作的频率和/或强度显着降低。结论：手术后生活质量显着提高，疼痛和肿胀减轻，并且容易瘀伤的可能性降低。脂肪水肿患者甲状腺功能减退症的高患病率可能与经常观察到的脂肪水肿相关肥胖有关。糖尿病、血脂异常和高血压的患病率较低似乎是脂肪水肿与生活方式引起的肥胖的一个具体特征。
Background: Although a large number of adult women worldwide are affected by lipedema, the physiologic conditions triggering onset and progression of this chronic disease remain enigmatic. In the present study, a descriptive epidemiologic situation of postoperative lipedema patients is presented. Methods: The authors developed an online survey questionnaire for lipedema patients in Germany. The survey was conducted on 209 female patients who had been diagnosed with lipedema and had undergone tumescent liposuction. Results: Most of the participants (average age, 38.5 years) had noticed a first manifestation of the disease at the age of 16. It took a mean of 15 years to accomplish diagnosis. Liposuction led to a significant reduction of pain, swelling, tenderness, and easy bruising as confirmed by the majority of patients. Hypothyroidism [n = 75 (35.9 percent) and depression [n = 48 (23.0 percent)] occurred at a frequency far beyond the average prevalence in the German population. The prevalence of diabetes type 1 [n = 3 (1.4 percent)], and diabetes type 2 [n = 2 (1 percent)] was particularly low among the respondents. Forty-seven of the lipedema patients (approximately 22.5 percent) suffered from a diagnosed migraine. Following liposuction, the frequency and/or intensity of migraine attacks became markedly reduced, as stated by 32 patients (68.1 percent). Conclusions: Quality of life increases significantly after surgery with a reduction of pain and swelling and decreased tendency to easy bruising. The high prevalence of hypothyroidism in lipedema patients could be related to the frequently observed lipedema-associated obesity. The low prevalence of diabetes, dyslipidemia, and hypertension appears to be a specific characteristic distinguishing lipedema from lifestyle-induced obesity.