Mesenchymal stem cell-derived exosome microRNA as therapy for cardiac ischemic injury
Mesenchymal stem cell-derived exosome microRNA as therapy for cardiac ischemic injury
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DOI：
10.1016/j.biopha.2021.112118
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发表时间：
2021-09-01
影响因子：
7.5
通讯作者：
Zhu, Ping
中科院分区：
文献类型：
--
作者：
Nasser, M., I;Masood, Muqaddas;Zhu, Ping
心血管疾病（CVD）是危害人类健康的重要原因。在过去，干细胞治疗被报道具有功能缺陷，如免疫排斥、致瘤性和输注毒性。外泌体是具有脂质双层膜结构的细胞外囊泡，含有蛋白质、脂质、mRNA、miRNA、DNA等分子，可介导多种生物学功能，如免疫应答、炎症反应、细胞迁移和分化细胞间通讯。外泌体miRNAs在疾病诊断和疗效预测方面具有突出的优势。同样，旁分泌因子也可以介导间充质干细胞的主要治疗作用。研究表明，间充质干细胞来源的微小外泌体（micro-exosomes）可能来源于干细胞，在移植后可在缺血组织中聚集，调节心肌损伤部位的细胞增殖、凋亡、炎症和血管生成。本文就骨髓间充质干细胞来源的exosomes和内部microRNAs在心肌缺血损伤修复中的分子机制作一综述。
Cardiovascular diseases (CVD) are a significant cause of human health harm. In the past, stem cell therapy was reported to have functional defects, such as immune rejection, tumorigenicity, and infusion toxicity. Exosomes are extracellular vesicles with lipid bilayer membrane structure, containing proteins, lipids, mRNA, miRNA, DNA, and other molecules, which can mediate various biological functions such as immune response, inflammatory response, cell migration, and differentiation intercellular communication. Exosomal miRNAs have outstanding advantages in disease diagnosis and curative effect prediction. Likewise, paracrine factors could also mediate the main therapeutic effect of mesenchymal stem cells. Research has shown that mesenchymal stem cellderived micro-exosomes, which may come from stem cells, accumulate in the ischemic tissue and regulate cell proliferation, apoptosis, inflammation, and angiogenesis sites of myocardial injury after being transplanted. This review reviewed the molecular mechanisms of exosomes and internal microRNAs derived from mesenchymal stem cells in cardiac ischemic injury repair.