Radiofrequency ablation versus hepatic resection for the treatment of early-stage hepatocellular carcinoma meeting Milan criteria: a systematic review and meta-analysis.
Radiofrequency ablation versus hepatic resection for the treatment of early-stage hepatocellular carcinoma meeting Milan criteria: a systematic review and meta-analysis.
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射频消融与肝切除术治疗早期肝细胞癌符合米兰标准：系统评价和荟萃分析。
DOI：
10.1186/1477-7819-11-190
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发表时间：
2013-08-13
影响因子：
3.2
通讯作者：
Bie P
中科院分区：
文献类型：
--
作者：
Duan C;Liu M;Zhang Z;Ma K;Bie P
目前符合米兰标准的早期HCC的治疗选择包括肝移植、肝切除（HR）、经导管动脉化疗栓塞（TACE）和射频消融（RFA）。HR或RFA是否是早期HCC更好的治疗方法长期以来一直存在争议。我们论文的目的是比较射频消融（RFA）和肝切除（HR）治疗早期肝细胞癌（HCC）的疗效。使用 MEDLINE、PubMed、Cochrane Library 和 EMBASE 数据库对 2013 年 6 月之前发表的评估 RFA 和 HR 治疗早期 HCC 疗效的对照试验进行电子检索。使用纳入和排除标准，荟萃分析中纳入了两项随机对照试验和 10 项非随机对照试验。结果显示，RFA术后3、5年总生存率和1、3、5年无病生存率均显着低于HR术后。然而，RFA 治疗后的并发症较少见，住院时间也显着缩短。此外，RFA 和 HR 之间的 1 年总生存率没有显着差异。结果显示，RFA与HR治疗小肝癌的短期疗效差异不显着，但HR的远期疗效优于RFA。然而，HR 与更多的并发症和更长的住院时间相关。
Current options for the treatment of the early-stage HCC conforming to the Milan criteria consist of liver transplantation, hepatic resection (HR), transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA) .Whether HR or RFA is the better treatment for early HCC has long been debated. The aim of our paper is to compare the therapeutic effects of radiofrequency ablation (RFA) and hepatic resection (HR) in the treatment of early-stage hepatocellular carcinoma (HCC). Controlled trials evaluating the efficacy between RFA and HR for the treatment of early-stage HCC published before June 2013 were searched electronically using MEDLINE, PubMed, Cochrane Library, and EMBASE databases. Using inclusion and exclusion criteria, two randomized controlled trials and 10 nonrandomized controlled trials were included in the meta- analysis. The results showed that the 3,5-year overall survival rates and 1,3,5 disease-free survival rates were significantly lower after RFA than after HR. However, complications after treatment were less common and the length of hospital stay was significantly shorter after RFA. Additionally, there was no significant difference in the 1-year overall survival rate between RFA and HR. The conclusions of the results show that the difference in the short-term effectiveness of RFA and HR in the treatment of small HCC is not notable, but the long-term efficacy of HR is better than that of RFA. However, HR is associated with more complications and a longer hospital stay.
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影响因子：
15.8
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
影响因子：
3.2
作者：
Montorsi, M;Santambrogio, R;Costa, M
通讯作者：
Costa, M
影响因子：
3.2
作者：
Huang, Jiwei;Hernandez-Alejandro, Roberto;Zeng, Yong
通讯作者：
Zeng, Yong
影响因子：
2.5
作者：
Lee, Kyung Keun;Kim, Dong Goo;Park, Jung Hyun
通讯作者：
Park, Jung Hyun
影响因子：
2.6
作者：
Guo, Wei-Xing;Zhai, Bo;Cheng, Shu-Qun
通讯作者：
Cheng, Shu-Qun