Nonlinear coupling of neural activity and CBF in rodent barrel cortex
Nonlinear coupling of neural activity and CBF in rodent barrel cortex
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DOI：
10.1016/j.neuroimage.2004.02.007
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发表时间：
2004-06-01
期刊：
影响因子：
5.7
通讯作者：
Mayhew, J
中科院分区：
文献类型：
--
作者：
Jones, M;Hewson-Stoate, N;Mayhew, J
神经活动和伴随的脑血流量（CBF）和氧合变化之间的关系，必须充分理解之前，脑成像技术的数据可以正确解释。功能磁共振成像中的信号是否反映了激活区域的神经输入或输出仍然不清楚。同样，神经活动和CBF变化之间的定量关系也没有很好地理解。本研究通过使用同步激光多普勒血流仪（LDF）测量CBF和多通道电生理记录场电位和多单位尖峰形式的神经活动来解决这些问题。我们证明，CBF激活耦合是一个非线性的反sigMoid函数。与以前的工作的数据比较表明，在一个皮质模型，CBF显示出最大的空间相关性与电流汇500妈妈对应的表面下的感觉输入。这些结果表明，在解释由特别强或弱的刺激引起的成像数据时必须小心，并且血液动力学变化可能更好地反映了对区域的输入而不是其尖峰输出。(C)2004爱思唯尔公司All rights reserved.
The relationship between neural activity and accompanying changes in cerebral blood flow (CBF) and oxygenation must be fully understood before data from brain imaging techniques can be correctly interpreted. Whether signals in fMRI reflect the neural input or output of an activated region is still unclear. Similarly, quantitative relationships between neural activity and changes in CBF are not well understood. The present study addresses these issues by using simultaneous laser Doppler flowmetry (LDF) to measure CBF and multichannel electrophysiology to record neural activity in the form of field potentials and multiunit spiking. We demonstrate that CBF-activation coupling is a nonlinear inverse sigMoid function. Comparing the data with previous work suggests that within a cortical model, CBF shows greatest spatial correlation with a current sink 500 mum below the surface corresponding to sensory input. These results show that care must be exercised when interpreting imaging data elicited by particularly strong or weak stimuli and that hemodynamic changes may better reflect the input to a region rather than its spiking output. (C) 2004 Elsevier Inc. All rights reserved.