Adult-born SVZ progenitors receive transient synapses during remyelination in corpus callosum.
Adult-born SVZ progenitors receive transient synapses during remyelination in corpus callosum.
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DOI：
10.1038/nn.2500
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发表时间：
2010-03
影响因子：
25
通讯作者：
Gallo V
中科院分区：
文献类型：
--
作者：
Etxeberria A;Mangin JM;Aguirre A;Gallo V
我们证明，在成年小鼠的胼胝体局部脱髓鞘后，脱髓鞘的轴突形成功能性的谷氨酸能突触，形成成年出生的NG2+少突胶质前体细胞(OPC)，从脑室下区(SVZ)迁移。损伤后一周，这种谷氨酸能输入显著减少，并在分化为少突胶质细胞时消失。因此，轴突-OP突触的形成是一个短暂的、受调节的步骤，发生在膝状体轴突的再髓鞘形成过程中。
We demonstrate that, after focal demyelination of adult mice corpus callosum, demyelinated axons form functional glutamatergic synapses onto adult-born NG2+ oligodendrocyte progenitor cells (OPCs) migrating from the subventricular zone (SVZ). One week after lesion, this glutamatergic input is significantly reduced compared to endogenous callosal OPCs, and is lost upon differentiation into oligodendrocytes. Therefore, axon-OP synapse formation is a transient and regulated step that occurs during remyelination of callosal axons.