Emergence of Complex Wave Patterns in Primate Cerebral Cortex
Emergence of Complex Wave Patterns in Primate Cerebral Cortex
复制标题
灵长类动物大脑皮层复杂波模式的出现
作者：
Rory G. Townsend;Selina S. Solomon;Spencer C. Chen;A. Pietersen;Paul R. Martin;S. Solomon;P. Gong
缓慢的脑节律归因于大脑神经元群活动的几乎同时（同步）变化。由于同步节律缓慢且分布广泛，因此人们并不认为它对清醒状态下的信息处理至关重要。在这里，我们采用湍流物理学的方法来分析麻醉绒猴大脑皮层多电极记录中局部场电位（LFP）活动的δ波段（1-4 Hz）节律。我们发现，同步只贡献了一小部分（小于四分之一）的局部时空结构的δ波段信号。相反，δ波段的活动主要是由传播的平面波和时空结构，我们称之为复波。复杂波在亚毫米空间尺度和毫秒范围的时间尺度上是明显的。我们表明，复杂的波可以其特征在于它们的关系，在当地的神经细胞网络的相位奇点。我们验证了复杂波的生物学相关性，表明神经细胞的尖峰速率是更高的存在下的复杂波比存在的同步性，并有非随机模式的演变，从一种类型的复杂波到另一种。我们的结论是，缓慢的脑节律主要表明局部神经细胞回路的时空组织活动，而不是大脑区域内和跨区域的同步活动。
Slow brain rhythms are attributed to near-simultaneous (synchronous) changes in activity in neuron populations in the brain. Because they are slow and widespread, synchronous rhythms have not been considered crucial for information processing in the waking state. Here we adapted methods from turbulence physics to analyze δ-band (1–4 Hz) rhythms in local field potential (LFP) activity, in multielectrode recordings from cerebral cortex in anesthetized marmoset monkeys. We found that synchrony contributes only a small fraction (less than one-fourth) to the local spatiotemporal structure of δ-band signals. Rather, δ-band activity is dominated by propagating plane waves and spatiotemporal structures, which we call complex waves. Complex waves are manifest at submillimeter spatial scales, and millisecond-range temporal scales. We show that complex waves can be characterized by their relation to phase singularities within local nerve cell networks. We validate the biological relevance of complex waves by showing that nerve cell spike rates are higher in presence of complex waves than in the presence of synchrony and that there are nonrandom patterns of evolution from one type of complex wave to another. We conclude that slow brain rhythms predominantly indicate spatiotemporally organized activity in local nerve cell circuits, not synchronous activity within and across brain regions.
影响因子：
2.5
作者：
Freeman, WJ;Barrie, JM
通讯作者：
Barrie, JM