Exploitation of physical and chemical constraints for three-dimensional microtissue construction in microfluidics
Exploitation of physical and chemical constraints for three-dimensional microtissue construction in microfluidics
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DOI：
10.1063/1.3593407
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发表时间：
2011-06-01
期刊：
影响因子：
3.2
通讯作者：
Yu, Hanry
中科院分区：
文献类型：
--
作者：
Choudhury, Deepak;Mo, Xuejun;Yu, Hanry
有大量的方法来构建微组织作为修复和再生更大的和复杂的组织的基石。在这里，我们重点研究了各种物理和化学捕获方法，用于在微流体系统中重现体内组织微观结构和功能的工程三维微组织结构。这些体外组织模型的进展使各种应用成为可能，包括药物筛选、疾病或损伤模型以及基于细胞的生物传感器。未来，我们将看到更精细的组织微观结构的中尺度控制，以及各种高通量应用的缩放设计。这些工具和知识将为生物医学应用的复杂内脏组织的精密工程奠定基础。(C) 2011年美国物理研究所。(doi: 10.1063/1.3593407)
There are a plethora of approaches to construct microtissues as building blocks for the repair and regeneration of larger and complex tissues. Here we focus on various physical and chemical trapping methods for engineering three-dimensional microtissue constructs in microfluidic systems that recapitulate the in vivo tissue microstructures and functions. Advances in these in vitro tissue models have enabled various applications, including drug screening, disease or injury models, and cell-based biosensors. The future would see strides toward the mesoscale control of even finer tissue microstructures and the scaling of various designs for high throughput applications. These tools and knowledge will establish the foundation for precision engineering of complex tissues of the internal organs for biomedical applications. (C) 2011 American Institute of Physics. [doi:10.1063/1.3593407]