INFERENCE OF SELECTION AND STOCHASTIC EFFECTS IN THE HOUSE MOUSE HYBRID ZONE
INFERENCE OF SELECTION AND STOCHASTIC EFFECTS IN THE HOUSE MOUSE HYBRID ZONE
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DOI：
10.1111/j.1558-5646.2011.01222.x
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发表时间：
2011-04-01
期刊：
影响因子：
3.3
通讯作者：
Pialek, Jaroslav
中科院分区：
文献类型：
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作者：
Dufkova, Petra;Macholan, Milos;Pialek, Jaroslav
我们探索了13个X连锁标记在家鼠杂交区的两个独立部分之间的转换，询问这样的比较是否可以区分选择的影响和随机因素。在似然图景中的启发式搜索揭示了在二维(2D)空间中采样的数据相对于沿线性横断面采样的数据的更复杂的似然分布。对个别位点的随机重抽样分析表明，删除远离区域中心的站点可以降低倾斜面宽度估计值，而删除靠近中心的站点可以显着增加宽度估计值。如果中心的样本数量有限，删除所有基因座的位置会导致更广泛的临床表现。结果表明，考虑到采样点的纳入/排除导致宽度估计的巨大差异，地理抽样设计在杂交区研究中是重要的，我们的推论应该考虑支持间隔等不确定性度量。两个断面的比较表明，X染色体中央部分的基因座的倾斜宽度较窄，这表明该区域的选择更强，遗传不亲和性可能至少在家鼠杂交区具有部分共同的结构。
We explored the transition of 13 X-linked markers across two separate portions of the house mouse hybrid zone, asking whether such a comparison can distinguish the effects of selection from random factors. A heuristic search in the likelihood landscape revealed more complex likelihood profiles for data sampled in two-dimensional (2D) space relative to data sampled along a linear transect. Randomized resampling of localities analyzed for individual loci showed that deletion of sites away from the zone center can decrease cline width estimates whereas deletion of sites close to the center can significantly increase the width estimates. Deleting localities for all loci resulted in wider clines if the number of samples from the center was limited. The results suggest that, given the great variation in width estimates resulting from inclusion/exclusion of sampling sites, the geographic sampling design is important in hybrid zone studies and that our inferences should take into account measures of uncertainty such as support intervals. The comparison of the two transects indicates cline widths are narrower for loci in the central part of the X chromosome, suggesting selection is stronger in this region and genetic incompatibilities may have at least partly common architecture in the house mouse hybrid zone.