Longitudinal movements and resulting shear strain of the arterial wall
Longitudinal movements and resulting shear strain of the arterial wall
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DOI：
10.1152/ajpheart.00988.2005
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发表时间：
2006-07-01
影响因子：
4.8
通讯作者：
Lindström, Kjell
中科院分区：
文献类型：
--
作者：
Cinthio, Magnus;Ahlgren, sa Rydén;Lindström, Kjell
人们对动脉壁的纵向运动很少感兴趣。已经假定，与直径变化相比，这种移动可以忽略不计。采用一种新的高分辨率无创超声方法，测量了10名健康人颈总动脉的纵向运动和直径变化。在心动周期中，所有受试者的内膜-中膜复合体都可以观察到明显的双向纵向运动。顺行纵向运动，即，在血流方向上，在收缩早期[ 0.39 mm（SD 0.26）]，随后是逆行纵向运动，即，在与血流方向相反的方向[ -0.52 mm（SD 0.27）]，随后在收缩期和第二次顺行纵向运动[ 0.41 mm（SD 0.33）]在二尖瓣。相应的直径变化为0.65 mm（SD 0.19）。外膜区域显示出相同的纵向运动基本模式;但是，运动幅度小于内膜-中膜复合体，从而引入了剪切应变，因此，壁内的剪切应力[内膜-中膜复合体和外膜区域之间的最大剪切应变为0.36 rad（SD 0.26）。这些现象以前没有被描述过。还对腹主动脉（n = 3）、肱动脉（n = 3）和腘动脉（n = 3）进行了测量。我们的新信息对于进一步研究和评价血管生物学和血流动力学，从而研究动脉粥样硬化和血管疾病具有重要意义。
There has been little interest in the longitudinal movement of the arterial wall. It has been assumed that this movement is negligible compared with the diameter change. Using a new high-resolution noninvasive ultrasonic method, we measured longitudinal movements and diameter change of the common carotid artery of 10 healthy humans. During the cardiac cycle, a distinct bidirectional longitudinal movement of the intima-media complex could be observed in all the subjects. An antegrade longitudinal movement, i.e., in the direction of blood flow, in early systole [ 0.39 mm ( SD 0.26)] was followed by a retrograde longitudinal movement, i.e., in the direction opposite blood flow [ -0.52 mm ( SD 0.27)], later in systole and a second antegrade longitudinal movement [ 0.41 mm ( SD 0.33)] in diastole. The corresponding diameter change was 0.65 mm ( SD 0.19). The adventitial region showed the same basic pattern of longitudinal movement; however, the magnitude of the movements was smaller than that of the intimamedia complex, thereby introducing shear strain and, thus, shear stress within the wall [ maximum shear strain between the intima-media complex and the adventitial region was 0.36 rad ( SD 0.26). These phenomena have not previously been described. Measurements were also performed on the abdominal aorta ( n = 3) and brachial ( n = 3) and popliteal ( n = 3) arteries. Our new information seems to be of fundamental importance for further study and evaluation of vascular biology and hemodynamics and, thus, for study of atherosclerosis and vascular diseases.