Structures of new sesquiterpenes and hepatoprotective constituents from the Egyptian herbal medicine Cyperus longus
Structures of new sesquiterpenes and hepatoprotective constituents from the Egyptian herbal medicine Cyperus longus
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DOI：
10.1021/np030368k
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发表时间：
2004-04-01
影响因子：
5.1
通讯作者：
Yoshikawa, M
中科院分区：
文献类型：
--
作者：
Xu, FM;Morikawa, T;Yoshikawa, M
从埃及香附全草中分离得到6个新的倍半萜，分别为香附醇A(1)(1)、A(2)(2)、B(3)、B-2(4)、C(5)和D(6)，以及2个单萜和13个倍半萜。根据化学和物理化学证据确定了新倍半萜的立体结构。此外，还发现主要成分对D-氨基半乳糖诱导的原代培养小鼠肝细胞毒性具有抑制作用。
Six new sesquiterpenes, cyperusols A(1) (1), A(2) (2), Bi (3), B-2 (4), C (5), and D (6), together with two monoterpenes and 13 sesquiterpenes were isolated from an Egyptian herbal medicine, the whole plants of Cyperus longus. The stereostructures of the new sesquiterpenes were determined on the basis of chemical and physicochemical evidence. In addition, the principal constituents were found to exhibit inhibitory activity on D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes.