Characterization of cavitation-radiated acoustic power using diffraction correction.
Characterization of cavitation-radiated acoustic power using diffraction correction.
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DOI：
10.1121/1.5083831
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发表时间：
2018-12
期刊：
影响因子：
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通讯作者：
Kyle T. Rich;C. Holland;M. Rao;T. D. Mast
中科院分区：
文献类型：
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作者：
Kyle T. Rich;C. Holland;M. Rao;T. D. Mast
开发了一种用于补偿由校准的被动空化检测器（PCD）进行的绝对压力测量的方法，以估计从定义为包含所有空化气泡的感兴趣区域（ROI）辐射的平均声功率。PCD测得的压力转换为空化辐射的声功率每单位面积或体积的衍射校正因子推导出作为一个简单的解析表达式，占位置和频率依赖的PCD的灵敏度。这种方法可以应用于由任何PCD进行的测量，而无需精确了解空化气泡的数量、空间或时间分布。衍射校正因子在模拟中针对广泛的ROI尺寸和频率进行了验证。校正因子也适用于在体外超声增强超声波电泳实验过程中获得的发射测量，允许治疗配置与不同的源中心频率之间的稳定的空化水平进行比较。结果将超声处理在0.41和2.0 MHz表明，皮肤渗透性的增加与每单位皮肤面积辐射的次谐波发射的声功率密切相关。
A method is developed for compensating absolute pressure measurements made by a calibrated passive cavitation detector (PCD) to estimate the average acoustic power radiated from a region of interest (ROI) defined to encompass all cavitating bubbles. A diffraction correction factor for conversion of PCD-measured pressures to cavitation-radiated acoustic power per unit area or volume is derived as a simple analytic expression, accounting for position- and frequency-dependent PCD sensitivity. This approach can be applied to measurements made by any PCD without precise knowledge of the number, spatial, or temporal distribution of cavitating bubbles. The diffraction correction factor is validated in simulation for a wide range of ROI dimensions and frequencies. The correction factor is also applied to emission measurements obtained during in vitro ultrasound-enhanced sonophoresis experiments, allowing comparison of stable cavitation levels between therapeutic configurations with different source center frequencies. Results incorporating sonication at both 0.41 and 2.0 MHz indicate that increases in skin permeability correlate strongly with the acoustic power of subharmonic emissions radiated per unit skin area.