PRENATAL EXPOSURE TO A LOW-FREQUENCY ELECTROMAGNETIC-FIELD DEMASCULINIZES ADULT SCENT MARKING BEHAVIOR AND INCREASES ACCESSORY SEX-ORGAN WEIGHTS IN RATS
PRENATAL EXPOSURE TO A LOW-FREQUENCY ELECTROMAGNETIC-FIELD DEMASCULINIZES ADULT SCENT MARKING BEHAVIOR AND INCREASES ACCESSORY SEX-ORGAN WEIGHTS IN RATS
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DOI：
10.1002/tera.1420410102
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发表时间：
1990-01-01
期刊：
影响因子：
--
通讯作者：
ADEY, WR
中科院分区：
文献类型：
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作者：
MCGIVERN, RF;SOKOL, RZ;ADEY, WR
从妊娠第 15 天到第 20 天，怀孕的 Sprague-Dawley 母鼠每天两次暴露在低水平、低频脉冲电磁 (EM) 场（15 Hz、0.3 毫秒、峰值强度 8 高斯）下，每次 15 分钟，妊娠第 15 天到第 20 天是雄性大鼠大脑性别分化的关键发育时期。在野外暴露的母鼠中，没有观察到产仔数、死产数或体重的差异。 120 天时，暴露在野外的雄性后代表现出的气味标记行为明显少于对照组。在这个年龄，暴露于野外的受试者的附属性器官重量，包括附睾、精囊和前列腺，显着较高。然而，睾酮、黄体生成素、卵泡刺激素的循环水平以及附睾精子计数均正常。这些数据表明，在神经行为性别分化的关键产前时期短暂、间歇性地暴露于低频电磁场可以使男性气味标记行为去男性化，并增加成年后副性器官的重量。
Pregnant Sprague-Dawley dams were exposed to a low-level, low-frequency pulsed electromagnetic (EM) field (15 Hz, 0.3 msec duration, peak intensity 8 gauss) for 15 min twice a day from day 15 through day 20 of gestation, a period in development that is critical for sexual differentiation of the male rat brain. No differences in litter size, number of stillborns, or body weight were observed in offspring from field-exposed dams. At 120 days of age, field-exposed male offspring exhibited significantly less scent marking behavior than controls. Accessory sex organ weights, including epididymis, seminal vesicles, and prostate, were significantly higher in field-exposed subjects at this age. However, circulating levels of testosterone, luteinizing hormone, and follicle-stimulating hormone as well as epididymal sperm counts, were normal. These data indicate that brief, intermittent exposure to low-frequency EM fields during the critical prenatal period for neurobehavioral sex differentiation can demasculinize male scent marking behavior and increase accessory sex organ weights in adulthood.