Characterization of metastatic heterogeneity among subpopulations of a single mouse mammary tumor: heterogeneity in phenotypic stability.
Characterization of metastatic heterogeneity among subpopulations of a single mouse mammary tumor: heterogeneity in phenotypic stability.
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发表时间：
1983
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通讯作者：
F. Miller;Miller Be;G. Heppner
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作者：
F. Miller;Miller Be;G. Heppner
通过将肿瘤细胞注射到侧尾静脉、乳腺脂肪垫或皮下组织中形成的转移的频率描述了单个自发产生的BALB/cfC 3 H小鼠乳腺肿瘤的8个亚群。这些亚群显示出所有三个注射部位的一系列转移行为。具有转移的动物的比例不取决于原发性肿瘤生长的部位（即，乳房脂肪垫与皮下组织）。一个亚群在静脉注射后可以生长为肺结节，但从皮下或脂肪垫植入物转移性很差。转移表型的稳定性在亚群之间的异质性是明显的。虽然大多数亚群及其克隆在2-5年内保持稳定，但一个亚群在3个月内迅速失去转移能力，另一个亚群在2年内逐渐变得更具转移性。
The frequency of metastasis formed by tumor cells injected into lateral tail veins, mammary fatpads, or the subcutis are described for eight subpopulations of a single, spontaneously arising BALB/cfC3H mouse mammary tumor. These subpopulations display a spectrum of metastatic behavior from all three injection sites. The proportion of animals with metastases does not depend upon the site of primary tumor growth (i.e., mammary fatpad versus subcutis). One subpopulation can grow as lung nodules after intravenous injection but is only poorly metastatic from subcutaneous or fatpad implants. Heterogeneity among the subpopulations in the stability of the metastatic phenotype is evident. Although most of the subpopulations and their clones remained stable for periods of 2-5 years, one subpopulation rapidly lost metastatic ability within 3 months and another gradually became more metastatic over 2 years.