Young Women with Cold-Activated Brown Adipose Tissue Have Higher Bone Mineral Density and Lower Pref-1 than Women without Brown Adipose Tissue: A Study in Women with Anorexia Nervosa, Women Recovered from Anorexia Nervosa, and Normal-Weight Women
Young Women with Cold-Activated Brown Adipose Tissue Have Higher Bone Mineral Density and Lower Pref-1 than Women without Brown Adipose Tissue: A Study in Women with Anorexia Nervosa, Women Recovered from Anorexia Nervosa, and Normal-Weight Women
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DOI：
10.1210/jc.2011-2246
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发表时间：
2012-04-01
影响因子：
5.8
通讯作者：
Klibanski, Anne
中科院分区：
文献类型：
--
作者：
Bredella, Miriam A.;Fazeli, Pouneh K.;Klibanski, Anne
背景：神经性厌食症(AN)与体脂消耗、骨密度(BMD)丢失和产热功能受损有关。棕色脂肪组织(BAT)在肥胖者中含量较低，随着年龄的增长而减少。目的：研究BAT在AN、康复AN(AN-R)和正常体重对照组中的存在和数量，研究BAT与BMD和身体成分的关系，并探讨BAT的激素预测因素。设计和背景：这是一项在临床研究中心进行的横断面研究。患者：15名女性，其中5名患有AN(平均年龄30+/-6.3岁)，5名AN-R，主要观察指标：荧光脱氧葡萄糖正电子发射断层扫描/计算机断层扫描确定冷激活的BAT。采用双能X线骨密度仪测定全身、脊柱、臀部、脂肪和瘦体重的骨密度。结果：AN组5例中1例阳性，AN-R组5例中2例阳性，健康非肥胖对照组5例中4例阳性。受试者根据BAT的存在(n=7)或不存在(n=8)进行分组。这两组人的年龄和体重指数相似。与无BAT的女性相比，有BAT的女性全身骨密度高，T3高，Pref-1低。BAT与BMD呈正相关，在控制疾病状态和体重指数后仍显著。结论：年轻女性BAT冷激活程度低，可能与BAT产热功能受损有关。与未患BAT的女性相比，患有BAT的年轻女性的BMD更高，Pref-1更低，提示BAT可能参与了干细胞向骨系分化的调节，但以牺牲脂肪生成为代价。(J临床内分泌Metab 97：E584-E590,2012)
Context: Anorexia nervosa (AN) is associated with depletion of body fat, loss of bone mineral density (BMD), and impaired thermogenesis. Brown adipose tissue (BAT) is lower in obese individuals and decreases during aging. Recent studies have suggested a link between BAT and bone metabolism.Objective: Our objective was to investigate the presence and quantity of BAT in patients with AN, recovered AN (AN-R), and normal-weight controls and to study the relationship between BAT and BMD and body composition and investigate hormonal predictors of BAT.Design and Setting: This was a cross-sectional study at a clinical research center.Patients: Patients included 15 women: five with AN (mean age 30 +/- 6.3 yr), five AN-R, and five healthy nonobese controls of comparable age.Main Outcome Measures: Cold-activated BAT was determined by fluorodeoxyglucose-positron emission tomography/computed tomography. BMD of total-body, spine, and hip, fat and lean mass was determined by dual-energy x-ray absorptiometry. Single-slice magnetic resonance imaging at L4 was done for abdominal fat compartments, and preadipocyte factor-1 (Pref-1), T-3, and T-4 were measured.Results: Within the AN group, one of five; in the AN-R group, two of five; and in the healthy nonobese control group, four of five subjects were BAT positive. Subjects were divided into groups based on the presence (n = 7) or absence (n = 8) of BAT. Both groups were of comparable age and body mass index. Women with BAT had higher total-body BMD, higher T3, and lower Pref-1 compared with women without BAT. There was a positive correlation between BAT and BMD that remained significant after controlling for disease status and body mass index.Conclusion: Young women with AN have low cold-activated BAT, which may be due to impaired BAT thermogenesis. Young women with BAT have higher BMD and lower Pref-1 compared with women without BAT, suggesting that BAT may be involved in the regulation of stem cell differentiation into the bone lineage at the expense of adipogenesis. (J Clin Endocrinol Metab 97: E584-E590, 2012)