A comprehensive review of the role of zinc in normal prostate function and metabolism; and its implications in prostate cancer.
A comprehensive review of the role of zinc in normal prostate function and metabolism; and its implications in prostate cancer.
复制标题
DOI：
10.1016/j.abb.2016.04.014
复制
发表时间：
2016-12-01
影响因子：
3.9
通讯作者：
Franklin, Renty B.
中科院分区：
文献类型：
--
作者：
Costello, Leslie C.;Franklin, Renty B.
关键词：
人类前列腺含有极高的锌含量；这是由于周围区域特化的积锌腺泡上皮所致。这些细胞的进化具有独特的能力，能够产生和分泌极高水平的柠檬酸盐，这是通过高细胞锌水平对细胞代谢的影响来实现的。本综述强调了高锌水平积累导致的特定功能和代谢变化，特别是其对线粒体柠檬酸代谢和末端氧化的影响。描述了锌在前列腺癌发生和进展中的影响，这是前列腺癌最一致的标志特征。 ZIP1 下调导致对锌的需求减少，以防止恶性细胞中的锌细胞毒性，这被描述为前列腺肿瘤发生中重要的早期事件。这为以下概念提供了基础：促进 ZIP1 缺陷的前列腺肿瘤细胞中锌的摄取和积累的药物（例如锌离子载体、氯碘羟喹）将显着抑制肿瘤生长。目前缺乏针对晚期前列腺癌和预防恶性肿瘤早期发展的有效化疗方法；锌治疗方案是一种应该采取的可行方法。
The human prostate gland contains extremely high zinc levels; which is due to the specialized zinc-accumulating acinar epithelial of the peripheral zone. These cells evolved for their unique capability to produce and secrete extremely levels of citrate, which is achieved by the high cellular zinc level effects on the cell metabolism. This review highlights the specific functional and metabolic alterations that result from the accumulation of the high zinc levels, especially its effects on mitochondrial citrate metabolism and terminal oxidation. The implications of zinc in the development and progression of prostate cancer are described, which is the most consistent hallmark characteristic of prostate cancer. The requirement for decreased zinc resulting from down regulation of ZIP1 to prevent zinc cytotoxicity in the malignant cells is described as an essential early event in prostate oncogenesis. This provides the basis for the concept that an agent (such as the zinc ionophore, clioquinol) that facilitates zinc uptake and accumulation in ZIP1-deficient prostate tumors cells will markedly inhibit tumor growth. In the current absence of an efficacious chemotherapy for advanced prostate cancer, and for prevention of early development of malignancy; a zinc treatment regimen is a plausible approach that should be pursued.
登录
查看更多内容
影响因子：
37.3
作者：
Costello, Leslie C;Franklin, Renty B
通讯作者：
Franklin, Renty B
BAX参与锌诱导的恶性前列腺细胞中的线粒体凋亡。
影响因子：
37.3
作者：
Feng, Pei;Li, Tieluo;Guan, Zhixin;Franklin, Renty B.;Costello, Leslie C.
通讯作者：
Costello, Leslie C.
DOI：
10.1016/j.bbrc.2005.04.170
发表时间：
2005-07-08
影响因子：
3.1
作者：
Feng, W;Cai, J;Kang, YJ
通讯作者：
Kang, YJ
影响因子：
3.9
作者：
Franklin, RB;Ma, J;Costello, LC
通讯作者：
Costello, LC
影响因子：
11.2
作者：
Ding, WQ;Liu, BL;Lind, SE
通讯作者：
Lind, SE