TFDP3 Regulates Epithelial-Mesenchymal Transition in Breast Cancer.
TFDP3 Regulates Epithelial-Mesenchymal Transition in Breast Cancer.
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TFDP3调节乳腺癌中的上皮间质转变。
DOI：
10.1371/journal.pone.0170573
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Yin K;Liu Y;Chu M;Wang Y
乳腺癌由于淋巴结转移、肿瘤微环境、继发性耐药等未知因素的影响，一直是女性的致命疾病。与乳腺癌相关的几种重要转录因子，如PTEN、p53和β-连环蛋白，已被鉴定并作为乳腺癌靶向治疗的候选者进行了深入研究。TFDP 3是一种新的，有前途的候选人在乳腺癌中的转录调控，虽然它是第一次发现在肝细胞癌。在这里，我们证明了TFDP 3在多种恶性肿瘤、正常睾丸组织和乳腺癌细胞系中表达，从而提供了TFDP 3是癌症睾丸抗原的证据。我们说明，过度表达或沉默TFDP 3干扰上皮-间充质转化，但不影响细胞增殖，表明TFDP 3蛋白在上皮-间充质转化过程中充当转录因子。这些数据强调了TFDP 3在乳腺癌中表达，它是癌症-睾丸抗原家族的成员，并且它在上皮-间充质转化中起调节剂的作用。
Breast cancer remains a lethal disease to women due to lymph node metastasis, the tumor microenvironment, secondary resistance and other unknown factors. Several important transcription factors involved in this disease, such as PTEN, p53 and beta-catenin, have been identified and researched in-depth as candidates for targeted therapy in breast cancer. TFDP3 is a new, promising candidate for transcriptional regulation in breast cancer, although it was first identified in hepatocellular carcinoma. Here, we demonstrate that TFDP3 is expressed in a variety of malignancies, normal testis tissue and breast cancer cell lines and thus provide evidence that TFDP3 is a cancer-testis antigen. We illustrate that overexpression or silencing TFDP3 interferes with epithelial-mesenchymal transition but does not influence cell proliferation, indicating that the TFDP3 protein acts as a transcription factor during epithelial-mesenchymal transition. These data highlight that TFDP3 is expressed in breast cancer, that it is a member of the cancer-testis antigen family and that it functions as a regulator in epithelial-mesenchymal transition.