RAC1: an emerging therapeutic option for targeting cancer angiogenesis and metastasis.
RAC1: an emerging therapeutic option for targeting cancer angiogenesis and metastasis.
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DOI：
10.1158/1535-7163.mct-13-0164
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发表时间：
2013-10
影响因子：
5.7
通讯作者：
Houghton PJ
中科院分区：
文献类型：
--
作者：
Bid HK;Roberts RD;Manchanda PK;Houghton PJ
血管生成和转移被公认为恶性肿瘤发展的基础过程。这两个过程都涉及通过无数信号网络协调多种细胞和化学活性，为治疗干预提供大量潜在靶点。本综述将集中在一个主调节细胞运动，RAC 1，和现有的数据，其在细胞运动中的作用，包括肿瘤血管生成和侵袭/转移的特殊作用。我们还强调使用RAC 1抑制剂进行的临床前研究，以评估该靶点的治疗潜力。在此，我们探讨了潜在的未来方向以及在癌症治疗中靶向RAC 1的挑战。最近在分子和细胞水平的见解是铺平了道路，一个更直接和详细的方法来靶向RAC 1调节血管生成和转移的机制。了解这些机制可能会提供深入了解RAC 1信号传导组件作为肿瘤血管生成和转移的替代治疗靶点。
Angiogenesis and metastasis are well recognized as processes fundamental to the development of malignancy. Both processes involve the coordination of multiple cellular and chemical activities through myriad signaling networks, providing a mass of potential targets for therapeutic intervention. This review will focus on one master regulator of cell motility, RAC1, and the existing data with regard to its role in cell motility, including particular roles for tumor angiogenesis and invasion/metastasis. We also emphasize the pre-clinical investigations carried out with RAC1 inhibitors to evaluate the therapeutic potential of this target. Herein we explore potential future directions as well as the challenges of targeting RAC1 in the treatment of cancer. Recent insights at the molecular and cellular levels are paving the way for a more directed and detailed approach to target mechanisms of RAC1 regulating angiogenesis and metastasis. Understanding these mechanisms may provide insight into RAC1 signaling components as alternative therapeutic targets for tumor angiogenesis and metastasis.