Association between C-reactive protein (CRP) level and physical performance in community-dwelling elderly in Japan
Association between C-reactive protein (CRP) level and physical performance in community-dwelling elderly in Japan
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DOI：
10.1016/j.archger.2009.10.002
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发表时间：
2010-09-01
影响因子：
4
通讯作者：
Suzuki, Takao
中科院分区：
文献类型：
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作者：
Yoshida, Yuko;Iwasa, Hajime;Suzuki, Takao
炎性细胞因子可能与老年人身体功能低下有关。本研究旨在探讨日本社区老年人循环中C-反应蛋白（CRP）水平与身体机能的关系。参与者为803名（329名男性和474名女性），年龄在65岁及以上。四个物理性能进行了评估，手握力，单腿站立的时间长度，步行速度（通常和最大）。低体能定义为每种性别中研究样本的最低25%。多因素Logistic回归分析显示，CRP与手握力成绩呈负相关（中位和最高位的OR = 1.86，95%可信区间= 95%CI = 1.32-3.05，OR = 2.92，95%CI = 1.53-5.58），单腿站立时间调整混杂因素后，中、高水平的OR = 1.96，95%CI = 1.28-3.00，OR = 2.16，95%CI = 1.19-3.92）和最大步行速度（最高水平的OR = 2.46，95%CI = 1.23-4.93）。结果显示，CRP水平与体能表现呈负相关，当调整混杂因素。CRP水平可能是检测老年人体力活动能力低下的一个有用指标。(C)2009爱思唯尔爱尔兰有限公司保留所有权利。
Inflammatory cytokines may contribute to lower physical function in elderly. The purpose of this study was to clarify the relation between circulating level of C-reactive protein (CRP) and physical performance among the community-dwelling elderly in Japan. Participants were 803 (329 men and 474 women) aged 65 years and over. Four physical performances were assessed using hand-grip strength, length of time standing on one leg, and walking speed (usual and maximal). Low physical performance was defined as the lowest 25% of study sample in each sex. Multiple logistic regression analysis showed that CRP was negatively associated with physical performance in hand-grip strength (odds ratio = OR = 1.86, 95% confidence interval = 95% CI = 1.32-3.05, OR = 2.92, 95% CI = 1.53-5.58, for the middle and highest, respectively), time of one leg standing (OR = 1.96, 95% CI = 1.28-3.00, OR = 2.16, 95% CI = 1.19-3.92, for the middle and highest, respectively) and maximal walking speed (OR = 2.46, 95% CI = 1.23-4.93, for the highest) when adjusted for the confounding factors. The results showed the negatively associated between CRP level and physical performance when adjusted for the confounding factors. CRP level may be a useful indicator for detecting the lower physical performance in elderly. (C) 2009 Elsevier Ireland Ltd. All rights reserved.