Association of hypogonadism and type II diabetes in men attending an outpatient erectile dysfunction clinic
Association of hypogonadism and type II diabetes in men attending an outpatient erectile dysfunction clinic
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DOI：
10.1038/sj.ijir.3901391
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发表时间：
2006-03-01
影响因子：
2.6
通讯作者：
Maggi, M
中科院分区：
文献类型：
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作者：
Corona, G;Mannucci, E;Maggi, M
与空腹血糖正常的受试者相比，糖尿病（DM）患者更容易出现性腺功能减退症。本研究的目的是评估与性腺功能减退症 (DMAH) 相关的 DM 的特征和心理生物学相关性。结构化访谈 SIEDY(C) 与多项生化、心理和仪器调查一起对 1200 多名勃起功能障碍 (ED) 患者进行了调查；其中 16% 患有 II 型糖尿病。性腺功能减退症定义为循环总睾酮 (T) 低于 10.4 nmol/l。 DM 中性腺功能减退的患病率为 24.5%，而其他样本中则为 12.6%（P < 0.0001）；调整年龄和体重指数后，性腺功能减退症患病率的差异仍然显着。 DMAH 与典型的性腺功能减退相关症状相关，例如性欲降低，导致性尝试次数减少，以及更高的抑郁症状。在 DMAH 中，睾丸大小和 LH 浓度显着减小，表明该疾病的中心起源。在阴茎双重超声检查中，与其他样本相比，糖尿病患者，特别是性腺功能减退的 II 型糖尿病患者，即使在调整了年龄和 BMI 后，仍表现出较低水平的基础和动态（注射 PGE(1) 后）峰值收缩速度和加速度。我们的研究结果表明，性腺功能减退症经常与 II 型糖尿病相关，至少在 6 世纪 10 年代是如此。 DMAH 可能会降低性欲和情绪，并进一步损害阴茎血管反应性，从而加剧性功能障碍。
Patients with diabetes mellitus (DM) were more often hypogonadal than normal fasting glucose subjects. The aim of this investigation is the assessment of characteristics and psychobiological correlates of DM associated with hypogonadism (DMAH). The Structured Interview SIEDY(C) was used along with several biochemical, psychological and instrumental investigations in a series of more than 1200 patients with erectile dysfunction (ED); 16% of whom with type II DM. Hypogonadism was defined as circulating total testosterone (T) below 10.4 nmol/l. The prevalence of hypogonadism was 24.5% in DM versus 12.6% in the rest of the sample (P < 0.0001); differences in the prevalence of hypogonadism retained significance after adjustment for age and BMI. DMAH was associated with typical hypogonadism-related symptoms, such as reduction in sexual desire, leading to a decreased number of sexual attempts, and with higher depressive symptomatology. In DMAH, testis size and LH concentrations were significantly reduced, suggesting a central origin of the disease. At penile Duplex ultrasound examination, diabetic patients and in particular hypogonadal type II diabetic patients showed lower levels of basal and dynamic (after PGE(1) injection) peak systolic velocity and acceleration, when compared to the rest of the sample, even after adjustment for age and BMI. Our results show that hypogonadism is frequently associated with type II DM, at least in the 6th decade. DMAH might exacerbate sexual dysfunction by reducing libido and mood and further compromising penile vascular reactivity.