Distribution of polybrominated diphenyl ethers in breast milk from North China: implication of exposure pathways.
Distribution of polybrominated diphenyl ethers in breast milk from North China: implication of exposure pathways.
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DOI：
10.1016/j.chemosphere.2008.12.030
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发表时间：
2009-03
期刊：
影响因子：
8.8
通讯作者：
Lingyan Zhu;B. Ma;Jingguang Li;Yongning Wu;Jin Gong
中科院分区：
文献类型：
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作者：
Lingyan Zhu;B. Ma;Jingguang Li;Yongning Wu;Jin Gong
2006年在中国天津采集的产妇母乳样本中的多溴联苯醚（PBDEs;八种同系物之和：BDE-28、47、99、100、153、154、183和209）浓度被测定（通过高分辨率气相色谱-高分辨率质谱法）。通过问卷调查获得参与者的饮食和生活习惯。多溴二苯醚总浓度（包括BDE-28、47、99、100、153、154、183）的中位数为2500 pgg − 1脂重，范围为1700至4500 pgg − 1脂重。这些水平与欧洲和日本的水平相同，但远低于北美的水平。中国的同系物概况也不同于其他国家。BDE-28的贡献率约为15%，远高于其他任何国家，这意味着中国市场可能使用了不同的五溴二苯醚配方。BDE-47、BDE-99和BDE-100的总和与BDE-153和BDE-154的总和之比较低，表明中国对八溴二苯醚产品的需求更大。研究发现，妇女体内多溴二苯醚的浓度与她使用电子设备的时间（h/d）之间存在着显著的相关性。这意味着电子产品是人们接触多溴二苯醚的一个潜在来源。吸入或摄入颗粒物质（如灰尘）也可能是一个重要的接触途径。多溴联苯醚浓度与肉类、鱼类和牛奶的消费量之间没有明显的相关性。需要进一步研究，以确定每种接触途径的具体作用及其对健康的影响。
The breast milk concentrations of polybrominated diphenyl ethers (PBDEs; sum of eight congeners: BDE-28, 47, 99, 100, 153, 154, 183 and 209) were determined (by high resolution gas chromatographic high resolution mass spectrometry) in samples from primiparous women collected in 2006 in Tianjin, China. Dietary and lifestyle habits of the participants were obtained by questionnaires. The median total PBDE concentration (including BDE-28, 47, 99, 100, 153, 154, 183) was 2500pgg−1lipid weight, ranging from 1700 to 4500pgg−1lipid weight. These levels were in the same range as those from Europe and Japan but much lower than those from North America. The congener profile in China was also different from other countries. The contribution of BDE-28 was around 15%, much higher than any other country, implying that a different Penta-BDE formulation might be used in the Chinese market. The lower ratio of the sum of BDE-47, 99, and 100 to the sum of BDE-153 and 154 suggested that Octa-products were in more demand in China. A significant correlation was found between a woman’s PBDE concentration and the time she used electronic appliances (h/d). This implies that electronics are a potential source of PBDEs to people. Inhalation or ingestion of particulate matter (such as dust) may also be an important exposure pathway. There was no significant correlation between the PBDE concentration and the consumption of meat, fish, and milk. Further research is needed to determine the specific contribution of each exposure route and their health effects.