Real-World Performance of a Self-Operated Home Monitoring System for Early Detection of Neovascular Age-Related Macular Degeneration.
Real-World Performance of a Self-Operated Home Monitoring System for Early Detection of Neovascular Age-Related Macular Degeneration.
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DOI：
10.3390/jcm10071355
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发表时间：
2021-03-25
影响因子：
3.9
通讯作者：
Eichenbaum DA
中科院分区：
文献类型：
--
作者：
Ho AC;Heier JS;Holekamp NM;Garfinkel RA;Ladd B;Awh CC;Singh RP;Sanborn GE;Jacobs JH;Elman MJ;Loewenstein A;Eichenbaum DA
家庭远程监控策略的真实世界性能（ForeseeHome AMD Monitoring System®，Notal Vision，Inc.，Manassas VA，USA），并在转化为新生血管性AMD（nAMD）的中度AMD（iAMD）患者中与AREDS 2-HOME研究的器械组进行比较。通过Notal Vision Diagnostic Clinic的病历识别了2009年10月至2018年9月期间使用家庭监测系统的所有确诊转为nAMD的患者。评价选定的结局变量，包括基线和转换时的视力（VA），以及从基线到转换时的视力（VA）变化。总计8991例患者进行了3，200，999次检测，频率为5.6 ± 3.2次/周。在研究期间从iAMD转换为nAMD的306只眼（年转换率为2.7%）被纳入分析。转换眼的中位数（四分位距）变化为−3.0（0.0-（−10.0））个字母，81% [95%置信区间（72-88%）]在转换时保持VA ≥ 20/40，而69%的转换检测由系统警报触发。家庭测试策略的真实世界性能与AREDS 2-HOME研究器械组报告的性能相似。家庭远程监护系统可以显著增加转化为nAMD的早期检测。
The real-world performance of a home telemonitoring strategy (ForeseeHome AMD Monitoring System®, Notal Vision, Inc.,Manassas VA, USA) was evaluated and compared to the device arm of the AREDS2-HOME study among patients with intermediate AMD (iAMD) who converted to neovascular AMD (nAMD). All patients with confirmed conversion to nAMD who used the home monitoring system from 10/2009 through 9/2018 were identified by Notal Vision Diagnostic Clinic’s medical records. Selected outcome variables were evaluated, including visual acuity (VA) at baseline and at conversion, and change in visual acuity (VA) from baseline to time of conversion. In total, 8991 patients performed 3,200,999 tests at a frequency of 5.6 ± 3.2 times/week. The 306 eyes that converted from iAMD to nAMD over the study period (a 2.7% annual rate) were included in the analyses. There was a median (interquartile range) change of −3.0 (0.0–(−10.0)) letters among converted eyes, 81% [95% confidence interval (72–88%)] maintained a VA ≥ 20/40 at the time of conversion, while 69% of the conversion detections were triggered by system alerts. The real-world performance of an at-home testing strategy was similar to that reported for the device arm of the AREDS2-HOME study. The home telemonitoring system can markedly increase early detection of conversion to nAMD.
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