The AQP structure and functional implications.
The AQP structure and functional implications.
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DOI：
10.1007/978-3-540-79885-9_2
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发表时间：
2009-01-01
影响因子：
--
通讯作者：
Engel, Andreas
中科院分区：
文献类型：
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作者：
Walz, Thomas;Fujiyoshi, Yoshinori;Engel, Andreas
AQP 结构测定的进展使人们对这些小的完整膜蛋白的水和溶质渗透有了深入的了解。现在可用的原子结构允许通过分子动力学模拟来监测水的渗透和质子的排除，并提供了通过定点突变详细评估水和溶质渗透的框架。尽管如此，仍需要进一步的结构和分子动力学分析来阐明调节以及气体渗透的基础，这些过程仍有待破译。
Progress in the structure determination of AQPs has led to a deep understanding of water and solute permeation by these small integral membrane proteins. The atomic structures now available have allowed the water permeation and exclusion of protons to be monitored by molecular dynamics simulations, and have provided a framework for assessing the water and solute permeation in great detail by site-directed mutations. In spite of this, further structural and molecular dynamics analyses are required to elucidate the basis for regulation as well as for gas permeation, processes that are still to be deciphered.