Chronic haloperidol or fluphenazine: effects on dopamine metabolism in brain, cerebrospinal fluid and plasma of Cercopithecus aethiops (vervet monkey).
Chronic haloperidol or fluphenazine: effects on dopamine metabolism in brain, cerebrospinal fluid and plasma of Cercopithecus aethiops (vervet monkey).
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慢性氟哌啶醇或氟奋乃静：对黑长尾猴（Cercopithecus aethiops）脑、脑脊液和血浆中多巴胺代谢的影响。
DOI：
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发表时间：
1980
影响因子：
3.5
通讯作者：
R. Roth
中科院分区：
文献类型：
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作者：
N. Bacopoulos;D. Redmond;J. Baulu;R. Roth
氟哌啶醇慢性治疗3至5周（0.5 mg/kg，每日）导致高香草酸（HVA）含量显着增加，在背侧和眶额皮质和扣带皮质。长期接受氟哌啶醇治疗的动物的嗅觉皮质、基底神经节、脑池脑脊液或血浆中未观察到HVA变化。用单次每周剂量的氟奋乃静癸酸酯（5 mg/kg）治疗3周导致所有上述脑区域、脑池脑脊液和血浆中的HVA水平增加。此外，氟奋乃静治疗组的锥体外系副作用发生率明显高于氟哌啶醇治疗组。它的结论是，慢性增加多巴胺代谢产物的生产在基底神经节，但不是在皮质是反映在脑脊液和血浆中的HVA水平的增加，并伴有严重的锥体外系副作用。
Chronic treatment with haloperidol for 3 to 5 weeks (0.5 mg/kg, daily) resulted in significant increases of homovanillic acid (HVA) content in dorsal and orbital frontal cortex and in cingulate cortex. No change in HVA was seen in the olfactory cortex, basal ganglia, cisternal cerebrospinal fluid or plasma of animals chronically treated with haloperidol. Treatment with a single weekly dose of fluphenazine decanoate (5 mg/kg) for 3 weeks resulted in increased HVA levels in all the above brain regions, cisternal cerebrospinal fluid and plasma. Moreover, the fluphenazine-treated group had a significantly higher incidence of extrapyramidal side effects than the haloperidol-treated group. It is concluded that chronically increased dopamine metabolite production in the basal ganglia but not in cortex is reflected by increases in the HVA level of cerebrospinal fluid and plasma and is accompanied by severe extrapyramidal side effects.