Secretory pattern of growth hormone (GH) in tall girls treated with Ethinyloestradiol (Oe)or Bromocriptine(B)
Secretory pattern of growth hormone (GH) in tall girls treated with Ethinyloestradiol (Oe)or Bromocriptine(B)
复制标题
乙炔雌二醇 (Oe) 或溴隐亭 (B) 治疗高个子女孩生长激素 (GH) 的分泌模式
作者：
O. Westphal;K. A. Wikland
To investigate GH dynamics in tall girls an integrated 24hGH-analysis has been performed in 12 tall pubertal girls collecting a sample every 20 min using a Kowarski-Cormed pump.The effect of Oe 500 ug daily (5pat) or B 5-7,5 mg(7pat) on spontaneous GH secretion has been studied by repeating the 24h analysis. On Oe treatment every girl increased the area under the curve, mean peak amplitude and the GH-level between peaks, so but less pronounced, did 4 out of 5 patients on B. On Oe the number of peaks was unchanged, on B slightly reduced. Somatomedin A (K.Hall) decreased during Oe-therapy, data yet not available on B. Growth-rate was reduced during Oe, unchanged on B treatment. The growth inhibiting effect of Oe is not mediated by GH but by SM and by acceleration of bone age. Growth inhibition of B if any, is unexplained.
