RGS2 determines short-term synaptic plasticity in hippocampal neurons by regulating Gi/o-mediated inhibition of presynaptic Ca2+ channels
RGS2 determines short-term synaptic plasticity in hippocampal neurons by regulating Gi/o-mediated inhibition of presynaptic Ca2+ channels
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DOI：
10.1016/j.neuron.2006.07.012
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发表时间：
2006-09-07
期刊：
影响因子：
16.2
通讯作者：
Herlitze, Stefan
中科院分区：
文献类型：
--
作者：
Han, Jing;Mark, Melanie D.;Herlitze, Stefan
RGS 2是G蛋白信号调节子（regulator of G protein signaling，RGS）家族的小成员之一，在脑内高度表达，并调节G（i/o）和G（q）偶联受体通路。RGS 2调节小鼠的焦虑、攻击性和血压，表明RGS 2调节动物生理和行为基础的突触回路。大脑中的RGS 2如何影响突触活动尚不清楚。因此，我们通过比较RGS 2基因敲除小鼠和野生型小鼠的电生理记录，分析了RGS 2在海马神经元中的突触功能。我们的研究通过证明RGS 2通过下调G（i/o）介导的突触前Ca 2+通道抑制来增加突触囊泡释放，从而提供了包含RGS 2的RGS家族的一般作用机制，并因此提供了对RGS 2表达的调节如何调节神经元回路潜在行为的功能的解释。
RGS2, one of the small members of the regulator of G protein signaling (RGS) family, is highly expressed in brain and regulates G(i/o) as well as G(q)-coupled receptor pathways. RGS2 modulates anxiety, aggression, and blood pressure in mice, suggesting that RGS2 regulates synaptic circuits underlying animal physiology and behavior. How RGS2 in brain influences synaptic activity is unknown. We therefore analyzed the synaptic function of RGS2 in hippocampal neurons by comparing electrophysiological recordings from RGS2 knockout and wild-type mice. Our study provides a general mechanism of the action of the RGS family containing RGS2 by demonstrating that RGS2 increases synaptic vesicle release by downregulating the G(i/o)-mediated presynaptic Ca2+ channel inhibition and therefore provides an explanation of how regulation of RGS2 expression can modulate the function of neuronal circuits underlying behavior.